Brainstem substructures and cognition in prodromal Alzheimer's disease.
Brainstem substructures and cognition in prodromal Alzheimer's disease.
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DOI：
10.1007/s11682-021-00459-y
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发表时间：
2021-10
影响因子：
3.2
通讯作者：
Alzheimer’s Disease Neuroimaging Initiative
中科院分区：
文献类型：
--
作者：
Dutt S;Li Y;Mather M;Nation DA;Alzheimer’s Disease Neuroimaging Initiative
神经病理学研究表明，阿尔茨海默病的tau病理可能起源于脑干核，但目前尚不清楚tau介导的脑干核变性是否会影响前驱阿尔茨海默病的认知障碍。本研究探讨了认知领域的影响前驱阿尔茨海默病和脑干子结构体积在认知正常的老年人（n = 814）和轻度认知障碍（n = 542）。认知正常（n = 112）和轻度认知障碍（n = 202）的子样本也具有脑脊液阿尔茨海默病生物标志物特征。感兴趣区域和体素水平分析将全脑干、中脑、脑桥和蓝斑体积与认知相关，多元线性回归模型校正了年龄、性别、教育、载脂蛋白-ε4携带状态和MRI磁场强度。在轻度认知障碍参与者中，较小的中脑和蓝斑体积与注意力和执行功能测试的较差表现显著相关，并且蓝斑体积与执行能力之间的关系在生物标志物证实的阿尔茨海默病的轻度认知障碍子样本中仍然显着。脑干掩蔽的体素回归进一步证明了蓝斑体积和执行能力之间的关联。脑干体积与记忆过程没有显着相关。研究结果表明，中脑和蓝斑体积与轻度认知障碍的注意力和执行力缺陷有关。结合先前的神经病理学研究，我们的数据表明阿尔茨海默病相关的脑干核变性与前驱阿尔茨海默病的认知缺陷之间存在联系。在线版本包含补充材料，可通过10.1007/s11682-021-00459-y获得。
Neuropathological research suggests the tau pathology of Alzheimer’s disease may originate in brainstem nuclei, yet it remains unknown whether tau-mediated degeneration of brainstem nuclei influences cognitive impairment in prodromal Alzheimer’s disease. The present study examined cognitive domains impacted in prodromal Alzheimer’s disease and brainstem substructure volume in cognitively normal older adults (n = 814) and those with mild cognitive impairment (n = 542). Subsamples of cognitively normal (n = 112) and mild cognitive impairment (n = 202) also had cerebrospinal fluid Alzheimer’s disease biomarker characterization. Region-of-interest and voxel-level analyses related whole brainstem, midbrain, pons, and locus coeruleus volumes to cognition with multiple linear regression models corrected for age, sex, education, apolipoprotein-ε4 carrier status, and MRI magnet strength. Within mild cognitive impairment participants, smaller midbrain and locus coeruleus volumes were significantly related to poorer performance on tests of attention and executive function, and the relationship between locus coeruleus volume and executive abilities remained significant in the mild cognitive impairment subsample with biomarker-confirmed Alzheimer’s disease. A brainstem-masked voxel-wise regression further demonstrated an association between locus coeruleus volume and executive abilities. Brainstem volumes were not significantly related to memory processes. Study findings implicate midbrain and locus coeruleus volume in attention and executive deficits in mild cognitive impairment. Together with prior neuropathological studies, our data suggest a link between Alzheimer’s disease-related degeneration of brainstem nuclei and cognitive deficits in prodromal Alzheimer’s disease. The online version contains supplementary material available at 10.1007/s11682-021-00459-y.
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影响因子：
7.7
作者：
Jacobs, Heidi Il;Priovoulos, Nikos;Uludag, Kamil
通讯作者：
Uludag, Kamil
影响因子：
4.2
作者：
Grudzien, Aneta;Shaw, Pamela;Mesulam, M. Marsel
通讯作者：
Mesulam, M. Marsel
影响因子：
10.6
作者：
Aston-Jones, G;Rajkowski, J;Cohen, J
通讯作者：
Cohen, J
影响因子：
9.9
作者：
Dutt, Shubir;Binney, Richard J.;Boxer, Adam L.
通讯作者：
Boxer, Adam L.
DOI：
10.1073/pnas.1712268115
发表时间：
2018-02-27
影响因子：
11.1
作者：
Hämmerer D;Callaghan MF;Hopkins A;Kosciessa J;Betts M;Cardenas-Blanco A;Kanowski M;Weiskopf N;Dayan P;Dolan RJ;Düzel E
通讯作者：
Düzel E