The Role of Gut Microbiota in Various Neurological and Psychiatric Disorders-An Evidence Mapping Based on Quantified Evidence.
The Role of Gut Microbiota in Various Neurological and Psychiatric Disorders-An Evidence Mapping Based on Quantified Evidence.
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肠道微生物群在各种神经和精神疾病中的作用——基于量化证据的证据图谱
DOI：
10.1155/2023/5127157
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发表时间：
2023
影响因子：
4.6
通讯作者：
Zhu, Yi
中科院分区：
文献类型：
--
作者：
Zang, Yaning;Lai, Xigui;Li, Conghui;Ding, Dongfang;Wang, Ying;Zhu, Yi
方法我们检索PubMed、科克伦图书馆和Epistemonikos，以确定系统评价和荟萃分析（SR）。我们检索了神经系统疾病和精神障碍，包括阿尔茨海默病（AD）、注意缺陷多动障碍（ADHD）、肌萎缩侧索硬化（ALS）、自闭症谱系障碍（ASD）、神经性厌食症（AN）、双相情感障碍（BD）、进食障碍（艾德）、广泛性焦虑症（GAD）、重度抑郁症（MDD）、多发性硬化症（MS）、强迫症（OCD）、帕金森病（PD）、创伤后应激障碍（PTSD）、脊髓损伤（SCI）、精神分裂症和中风。我们使用评估系统评价的测量工具（AMSTAR-2）来评估纳入SR的质量。我们还创建了一个证据图，显示了肠道微生物群在神经系统疾病中的作用以及证据的确定性。结果共纳入42篇文献。大多数发现来自观察性研究。根据AMSTAR-2评估，21名SR在方法学质量方面得分"极低"，16名SR得分"低"，5名SR得分"中等"。共有15种疾病被调查了肠道微生物组α多样性与疾病之间的潜在关联，其中香农指数和辛普森指数是研究最广泛的。共调查了12种疾病，以确定β多样性与疾病之间的潜在联系。在门的水平上，厚壁菌门、拟杆菌门、放线菌门、变形菌门和疣微菌门的研究较多。在属的水平上，研究较多的有普雷沃菌属、粪球菌属、副拟杆菌属、乳杆菌属、志贺埃希菌属、阿里柄菌属、萨特拉菌属、韦荣氏球菌属、气味杆菌属、粪杆菌属、拟杆菌属、双歧杆菌属、小杆菌属和布劳特氏菌属。有些疾病被发现有特定的植物群变化，有些疾病被发现有共同的肠道微生物变化。结论我们发现了不同程度的证据表明肠道微生物群与神经系统疾病之间存在关联;一些肠道微生物群增加了神经系统疾病的风险，而另一些肠道微生物群则显示出有益的证据，表明肠道微生物群可能是此类疾病有希望的治疗靶点。
Methods We searched PubMed, Cochrane Library, and Epistemonikos to identify systematic reviews and meta-analysis (SRs). We searched for neurological diseases and psychiatric disorders, including Alzheimer's disease (AD), attention deficit hyperactivity disorder (ADHD), amyotrophic lateral sclerosis (ALS), autism spectrum disorder (ASD), anorexia nervosa (AN), bipolar disorder (BD), eating disorder (ED), generalized anxiety disorder (GAD), major depressive disorder (MDD), multiple sclerosis (MS), obsessive compulsive disorder (OCD), Parkinson's disease (PD), posttraumatic stress disorder (PTSD), spinal cord injury (SCI), schizophrenia, and stroke. We used A Measurement Tool to Assess Systematic Reviews (AMSTAR-2) to evaluate the quality of included SRs. We also created an evidence map showing the role of gut microbiota in neurological diseases and the certainty of the evidence. Results In total, 42 studies were included in this evidence mapping. Most findings were obtained from observational studies. According to the AMSTAR-2 assessment, 21 SRs scored “critically low” in terms of methodological quality, 16 SR scored “low,” and 5 SR scored “moderate.” A total of 15 diseases have been investigated for the potential association between gut microbiome alpha diversity and disease, with the Shannon index and Simpson index being the most widely studied. A total of 12 diseases were investigated for potential link between beta diversity and disease. At the phylum level, Firmicutes, Bacteroidetes, Actinobacteria, Proteobacteria, and Verrucomicrobia were more researched. At the genus level, Prevotella, Coprococcus, Parabacteroides, Phascolarctobacterium, Escherichia Shigella, Alistipes, Sutteralla, Veillonella, Odoribacter, Faecalibacterium, Bacteroides, Bifidobacterium, Dialister, and Blautia were more researched. Some diseases have been found to have specific flora changes, and some diseases have been found to have common intestinal microbiological changes. Conclusion We found varied levels of evidence for the associations between gut microbiota and neurological diseases; some gut microbiota increased the risk of neurological diseases, whereas others showed evidence of benefit that gut microbiota might be promising therapeutic targets for such diseases.
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影响因子：
2.7
作者：
Asadi A;Shadab Mehr N;Mohamadi MH;Shokri F;Heidary M;Sadeghifard N;Khoshnood S
通讯作者：
Khoshnood S
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影响因子：
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3.9
作者：
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影响因子：
3.3
作者：
Chen LL;Abbaspour A;Mkoma GF;Bulik CM;Rück C;Djurfeldt D
通讯作者：
Djurfeldt D
影响因子：
2.5
作者：
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通讯作者：
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