Composite Lymphomas and the Relationship of Hodgkin Lymphoma to Non-Hodgkin Lymphomas
Composite Lymphomas and the Relationship of Hodgkin Lymphoma to Non-Hodgkin Lymphomas
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复合淋巴瘤以及霍奇金淋巴瘤与非霍奇金淋巴瘤的关系
DOI：
10.1007/978-3-319-68094-1_7
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Küppers R
中科院分区：
文献类型：
--
作者：
Weniger MA;Küppers R
复合淋巴瘤是两种不同类型的淋巴瘤同时发生在一名患者身上的罕见组合，通常是霍奇金淋巴瘤（HL）和非霍奇金淋巴瘤（NHL）。在其他情况下，患者可能随后发生HL和NHL。有些复合性淋巴瘤可能是两个独立肿瘤的偶发。然而，在很大一部分合并HL和NHL中，这两种淋巴瘤是克隆相关的，因此具有共同的起源。对这类相关淋巴瘤免疫球蛋白V区重排基因的详细分析提供了强有力的证据，表明在许多情况下，两种复合淋巴瘤以及连续的HL和b细胞NHL是由突变的生发中心（GC） b细胞克隆的不同子细胞发展而来的。克隆相关的复合淋巴瘤既携带共同的早期遗传病变，也携带后来单独的转化事件，支持这种情况下的多步骤转化过程。克隆相关免疫球蛋白V区基因的模式和共同的遗传病变表明HL与b细胞NHL密切相关。以结节淋巴细胞为主的HL在组织学和表型上与滤泡性淋巴瘤有许多相似之处。两种淋巴瘤的肿瘤细胞均为转化的GC B细胞，但两种淋巴瘤的癌基因和抑癌基因突变模式不同。与经典HL关系最密切的淋巴瘤是原发性纵隔b细胞淋巴瘤（PMBL）和间变性大细胞淋巴瘤（ALCL）。经典HL和PMBL共享许多组成性激活的信号通路，并在其遗传病变模式中显示出大量重叠，但淋巴瘤细胞似乎来自两个不同的GC B细胞亚群。cHL和ALCL的淋巴瘤细胞也共享许多不受调节的信号通路，以及形态学和表型特征，但一个主要的区别是经典HL的b细胞起源和ALCL的t细胞起源。
Composite lymphomas are rare combinations of two distinct types of lymphomas occurring simultaneously in one patient, often a Hodgkin lymphoma (HL) and a non-Hodgkin lymphoma (NHL). In other instances, a HL and a NHL may occur subsequently in a patient. Some composite lymphomas likely represent chance occurrences of two independent tumors. However, in a large fraction of combined HL and NHL, the two lymphomas are clonally related and hence have a common origin. Detailed analysis of the rearranged immunoglobulin V region genes of such related lymphomas provided strong evidence that in many cases, the two lymphomas in composite as well as consecutive HL and B-cell NHL developed from distinct daughter cells of a mutating germinal center (GC) B-cell clone. Clonally related composite lymphomas carry both shared early genetic lesions as well as later separate transforming events, supporting a multi-step transformation process in such cases. The pattern of clonally related immunoglobulin V region genes and shared genetic lesions points to a close relationship of HL to B-cell NHL.Nodular lymphocyte predominant HL shows numerous histological and phenotypic similarities to follicular lymphoma. The tumor cells of both lymphomas represent transformed GC B cells, but the two lymphomas differ in their patterns of mutated oncogenes and tumor suppressor genes. The lymphomas most closely related to classical HL are primary mediastinal B-cell lymphoma (PMBL) and anaplastic large cell lymphoma (ALCL). Classical HL and PMBL share many constitutively activated signaling pathways and show a large overlap in their patterns of genetic lesions, but the lymphoma cells seem to derive from two distinct subsets of GC B cells. The lymphoma cells in cHL and ALCL also share a number of deregulated signaling pathways, as well as morphological and phenotypical features, but a major distinction is the B-cell derivation of classical HL and the T-cell origin of ALCL.
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经典霍奇金病 Reed-Sternberg 细胞中克隆 T 细胞受体 γ 链基因重排的检测。
影响因子：
20.3
作者：
V. Seitz;M. Hummel;Theresa Marafioti;I. Anagnostopoulos;C. Assaf;H. Stein
通讯作者：
H. Stein
MALT 型淋巴瘤患者霍奇金病和 CD30 弥漫性大 B 细胞淋巴瘤的相继发展：单个显微解剖 Reed-Sternberg 细胞不同克隆起源的证据
影响因子：
5.6
作者：
M. Parrens;B. Vergier;O. Fitoussi;C. Lahet;G. Belléannée;G. Marit;P. Dubus;A. de Mascarel;M. Delfau;J. Merlio
通讯作者：
J. Merlio
影响因子：
29.7
作者：
Shaffer AL 3rd;Young RM;Staudt LM
通讯作者：
Staudt LM
影响因子：
6.5
作者：
Carbone, A;Gloghini, A;Gaidano, G
通讯作者：
Gaidano, G
对霍奇金病中 t(14;18)(q32;q21) 染色体易位的单细胞分析表明，肿瘤性霍奇金细胞和 Reed-Sternberg 细胞中不存在这种易位。
影响因子：
20.3
作者：
S. Gravel;G. Delsol;T. al Saati
通讯作者：
T. al Saati