Protective effect of breastfeeding on recurrent cough in adulthood.
Protective effect of breastfeeding on recurrent cough in adulthood.
复制标题
母乳喂养对成年后反复咳嗽的保护作用。
DOI：
10.1136/thoraxjnl-2017-210841
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发表时间：
2018-09
期刊：
影响因子：
10
通讯作者：
Wright AL
中科院分区：
文献类型：
--
作者：
Gerhart KD;Stern DA;Guerra S;Morgan WJ;Martinez FD;Wright AL
母乳喂养可以预防早期的呼吸道感染，但它与成人生活中反复咳嗽和其他呼吸道结果的关系尚未得到很好的证实。婴儿喂养实践在图森儿童呼吸研究中进行了前瞻性评估，这是一个非选定的出生队列，分为从出生或引入1个月配方奶粉，引入≥1至4个月配方奶粉，以及纯母乳喂养≥4个月。婴儿喂养被评估为代表三个类别中母乳剂量增加的序数变量。复发性咳嗽的定义为22年、26年和32年，即在过去一年中≥2次咳嗽而没有感冒持续1周。协变量包括参与者的性别、种族/民族和吸烟，以及父母吸烟、教育程度、年龄和哮喘。协变量被评估为婴儿喂养和成人结局之间关系的潜在混杂因素。在786名参与者中，19%的人母乳喂养1个月，50%的人母乳喂养≥1至4个月，31%的人母乳喂养≥4个月。22岁、26岁和32岁时咳嗽复发率分别为17%、15%和16%。每一次母乳喂养时间的增加与成人生活中反复咳嗽的风险降低相关：调整后的OR=0.71，(95%CI：0.56至0.89)，p=0.004。对并发的成人哮喘、喘息、吸烟和肺容量进行额外的调整并没有改变这些结果。无论吸烟和其他呼吸道症状如何，较长时间的母乳喂养都会降低成年后反复咳嗽的风险，这表明对呼吸健康有长期的保护作用。
Breastfeeding protects from respiratory infections in early life but its relationship to recurrent cough and other respiratory outcomes in adult life is not well established. Infant feeding practices were assessed prospectively in the Tucson Children’s Respiratory Study, a non-selected birth cohort and categorised into formula from birth or introduced <1 month, formula introduced ≥1 to <4 months and exclusive breastfeeding for ≥4 months. infant feeding was assessed as an ordinal variable representing an increasing dose of breastmilk across the three categories. Recurrent cough was defined at 22, 26 and 32 years as ≥2 episodes of cough without a cold lasting 1 week during the past year. Covariates included participant sex, race/ethnicity and smoking as well as parental smoking, education, age and asthma. Covariates were evaluated as potential confounders for the relation between infant feeding and adult outcomes. Of the 786 participants, 19% breastfed <1 month, 50% breastfed ≥1 to <4 months and 31% breastfed ≥4 months. The prevalence of recurrent cough at 22, 26 and 32 years was 17%, 15% and 16%, respectively. Each ordinal increase in breastfeeding duration was associated with a decreased risk of recurrent cough in adult life: adjusted OR=0.71, (95% CI: 0.56 to 0.89), p=0.004. Additional adjustment for concurrent adult asthma, wheeze, smoking and lung volume did not change these results. Longer duration of breastfeeding reduces the risk of recurrent cough in adult life, regardless of smoking and other respiratory symptoms, suggesting long-term protective effects on respiratory health.
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DOI：
10.1164/ajrccm.156.6.9612066
发表时间：
1997-12-01
影响因子：
24.7
作者：
Lombardi, E;Morgan, WJ;Martinez, FD
通讯作者：
Martinez, FD
影响因子：
10
作者：
Bridevaux, P-O;Gerbase, M. W.;Rochat, T.
通讯作者：
Rochat, T.
影响因子：
5.6
作者：
Rigas, A;Rigas, B;Trichopoulos, D
通讯作者：
Trichopoulos, D
DOI：
10.1111/cea.12573
发表时间：
2015-09
期刊：
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
影响因子：
--
作者：
Oren E;Rothers J;Stern DA;Morgan WJ;Halonen M;Wright AL
通讯作者：
Wright AL
影响因子：
168.9
作者：
Stein, R;Sherrill, D;Martinez, FD
通讯作者：
Martinez, FD