Spermatogenesis associated retrogenes are expressed in the human ovary and ovarian cancers.
Spermatogenesis associated retrogenes are expressed in the human ovary and ovarian cancers.
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DOI：
10.1371/journal.pone.0005064
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发表时间：
2009
期刊：
影响因子：
3.7
通讯作者：
Bishop CE
中科院分区：
文献类型：
--
作者：
Rohozinski J;Anderson ML;Broaddus RE;Edwards CL;Bishop CE
卵巢癌是女性第二常见的妇科癌症。然而，它是迄今为止最致命的。这通常归因于缺乏可用于早期诊断和特定治疗靶点的卵巢癌特异性标记物。使用终点PCR，我们发现，以前认为仅在男性精子发生过程中的男性睾丸中表达的逆转录基因家族，也在正常卵巢组织和大部分卵巢癌中表达。人类中至少有 11 个这样的常染色体逆转录基因，它们是 X 染色体上基因的无内含子副本，对于正常精子发生至关重要，并在人类睾丸中特异性表达。我们测试了五种已知的逆转录基因：UTP14C、PGK2、RPL10L、RPL39L 和 UBL4B 在正常人卵巢和卵巢癌中的表达。我们认为，卵巢和卵巢癌中睾丸特异性逆转录基因的激活对人类具有生物学意义。由于这些逆转录基因在女性卵巢和卵巢癌中特异性表达，因此它们可能有助于开发卵巢癌的新诊断和/或治疗靶点。
Ovarian cancer is the second most prevalent gynecologic cancer in women. However, it is by far the most lethal. This is generally attributed to the absence of easily detectable markers specific to ovarian cancers that can be used for early diagnosis and specific therapeutic targets. Using end point PCR we have found that a family of retrogenes, previously thought to be expressed only in the male testis during spermatogenesis in man, are also expressed in normal ovarian tissue and a large percentage of ovarian cancers. In man there are at least eleven such autosomal retrogenes, which are intronless copies of genes on the X chromosome, essential for normal spermatogenesis and expressed specifically in the human testis. We tested for the expression of five of the known retrogenes, UTP14C, PGK2, RPL10L, RPL39L and UBL4B in normal human ovary and ovarian cancers. We propose that the activation of the testis specific retrogenes in the ovary and ovarian cancers is of biological significance in humans. Because these retrogenes are specifically expressed in the ovary and ovarian cancers in the female they may prove useful in developing new diagnostic and/or therapeutic targets for ovarian cancer.
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DOI：
10.1084/jem.179.3.921
发表时间：
1994-03-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Gaugler B;Van den Eynde B;van der Bruggen P;Romero P;Gaforio JJ;De Plaen E;Lethé B;Brasseur F;Boon T
通讯作者：
Boon T
影响因子：
8
作者：
Edelson, MI;Lau, CC;Mok, SC
通讯作者：
Mok, SC
影响因子：
32.4
作者：
BOEL, P;WILDMANN, C;VANDERBRUGGEN, P
通讯作者：
VANDERBRUGGEN, P
影响因子：
64.8
作者：
Dragon, F;Gallagher, JEG;Baserga, SJ
通讯作者：
Baserga, SJ
DOI：
10.1073/pnas.94.5.1914
发表时间：
1997-03-04
影响因子：
11.1
作者：
Chen, YT;Scanlan, MJ;Old, LJ
通讯作者：
Old, LJ