Muscarinic cholinergic modulation of prepulse inhibition of the acoustic startle reflex.
Muscarinic cholinergic modulation of prepulse inhibition of the acoustic startle reflex.
复制标题
声音惊吓反射的前脉冲抑制的毒蕈碱胆碱能调节。
DOI：
--
复制
发表时间：
2000
影响因子：
3.5
通讯作者：
H. Shannon
中科院分区：
文献类型：
--
作者：
C. K. Jones;H. Shannon
本研究的目的是确定毒蕈碱胆碱能受体拮抗剂和激动剂对大鼠声惊吓反射的前脉冲抑制（PPI）的影响。毒蕈碱受体拮抗剂东莨菪碱（0.03-1.0 mg/kg）产生了显着的剂量依赖性降低PPI，而不影响惊吓幅度。相反，东莨菪碱的季铵类似物N-甲基东莨菪碱对PPI没有影响，表明东莨菪碱通过中枢胆碱能机制破坏PPI。另外两种毒蕈碱受体拮抗剂苯海索（0.3-10 mg/kg）和苯扎托品（0.03-10 mg/kg）与东莨菪碱相似，可显著降低PPI。而毒蕈碱受体拮抗剂双环胺（0.03 ~ 10 mg/kg）和比哌立登（0.03 ~ 10 mg/kg）对PPI无影响，但显著降低惊吓幅度。烟碱受体拮抗剂美加明（0.1-10 mg/kg）对PPI也无影响。单独给药，毒蕈碱受体激动剂毛果芸香碱（0. 0.01-0.3 mg/kg）、RS-86（0.1 -3.0 mg/kg）和槟榔碱（0.3-10 mg/kg）以及胆碱酯酶抑制剂毒扁豆碱（0.01-0.3 mg/kg）和他克林（0.03-10 mg/kg）对PPI没有影响，但在最高测试剂量下，每种药物都能显著降低惊吓幅度。此外，东莨菪碱对PPI的破坏被毒蕈碱受体激动剂oxotremorine以剂量依赖性方式逆转。本研究结果表明，毒蕈碱胆碱能系统在PPI的正常机制中起着重要作用。
The purpose of the present study was to determine the effects of muscarinic cholinergic receptor antagonists and agonists on prepulse inhibition (PPI) of the acoustic startle reflex in rats. The muscarinic receptor antagonist scopolamine (0.03-1.0 mg/kg) produced a significant dose-dependent decrease in PPI without affecting startle amplitude. In contrast, N-methyl scopolamine, the quaternary analog of scopolamine, had no effect on PPI, indicating that scopolamine disrupted PPI through a central cholinergic mechanism. Two other muscarinic receptor antagonists, trihexyphenidyl (0.3-10 mg/kg) and benztropine (0.03-10 mg/kg), produced significant decreases in PPI similar to scopolamine. On the other hand, the muscarinic receptor antagonists dicyclomine (0.03-10 mg/kg) and biperiden (0.03-10 mg/kg) had no effect on PPI but significantly decreased startle amplitude. Mecamylamine (0.1-10 mg/kg), a nicotinic receptor antagonist, also had no effect on PPI. Administered alone, the muscarinic receptor agonists pilocarpine (0. 03-10 mg/kg), oxotremorine (0.01-0.3 mg/kg), RS-86 (0.1-3.0 mg/kg), and arecoline (0.3-10 mg/kg), as well as the cholinesterase inhibitors physostigmine (0.01-0.3 mg/kg) and tacrine (0.03-10 mg/kg), had no effect on PPI, but each produced significant decreases in startle amplitude at the highest doses tested. In addition, the disruption of PPI by scopolamine was reversed in a dose-dependent manner by the muscarinic receptor agonist oxotremorine. The present findings demonstrate that the muscarinic cholinergic system plays an important role in the normal mechanisms of PPI.
登录
查看更多内容
DOI：
--
发表时间：
1992-02
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
C. Bolden;B. Cusack;Elliott Richelson
通讯作者：
C. Bolden;B. Cusack;Elliott Richelson
惊吓和前脉冲抑制中的胆碱能机制：假胆碱能前体 N-氨基脱醇的作用。
影响因子：
1.9
作者：
Wu,MF;Jenden,DJ;Fairchild,MD;Siegel,JM
通讯作者：
Siegel,JM
影响因子：
56.9
作者：
MASH, DC;FLYNN, DD;POTTER, LT
通讯作者：
POTTER, LT
影响因子：
--
作者：
D. Braff;C. Grillon;M. Geyer
通讯作者：
D. Braff;C. Grillon;M. Geyer
脚桥被盖核损伤后大鼠声惊吓的前脉冲抑制。
影响因子：
1.9
作者：
Swerdlow,NR;Geyer,MA
通讯作者：
Geyer,MA