Obesity promotes melanoma tumor growth: role of leptin.
Obesity promotes melanoma tumor growth: role of leptin.
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DOI：
10.4161/cbt.8.19.9650
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发表时间：
2009-10
影响因子：
3.6
通讯作者：
Hall JE
中科院分区：
文献类型：
--
作者：
Brandon EL;Gu JW;Cantwell L;He Z;Wallace G;Hall JE
流行病学研究表明，肥胖会增加患几种癌症的风险，包括黑色素瘤。肥胖增加血管生成因子的表达，如瘦素，这可能有助于肿瘤生长。然而，肥胖和肿瘤生长之间的直接因果关系尚未明确建立，瘦素在加速肿瘤生长中的作用尚不清楚。本研究的目的是检测瘦素缺乏或血浆瘦素水平高的瘦小鼠和肥胖小鼠的黑色素瘤生长率。我们将1 × 10 B16 F10黑色素瘤细胞皮下注射到瘦野生型（WT）、肥胖黑皮质素受体4敲除（MC 4 R −/−）（具有高瘦素水平）、肥胖瘦素缺陷（ob −/−）、成对喂养的瘦ob−/−和瘦ob+/−小鼠中。平均体重分别为29.7 ± 0.3 g（WT）、46.3 ± 1.9 g（MC 4 R −/−）、63.7 ± 0.9 g（ob−/−）、30.5 ± 1.0 g（配对喂养ob−/−）和31.6 ± 1.7 g（ob+/−）。肥胖的瘦素缺乏小鼠（5.1 ± 0.9 g）和肥胖的MC 4 R小鼠（5.1 ± 0.7 g）的肿瘤比瘦的WT小鼠（1.9 ± 0.3 g）和肥胖的肥胖小鼠（2.8 ± 0.7 g）的肿瘤大得多。通过配对喂养ob−/−小鼠来预防肥胖，显著降低了肿瘤重量（0.95 ± 0.2 g），其水平显著低于相同重量的WT小鼠。无论宿主瘦素水平如何，肥胖小鼠肿瘤中的肿瘤VEGF水平最高（p < 0.05）。除瘦型ob+/−外，MC 4 R −/−和ob−/−黑色素瘤的VEGF受体1和VEGF受体2蛋白表达最高（分别为p < 0.01和p < 0.05）。这些结果表明，肥胖通过可能涉及VEGF途径上调的机制显著增加黑色素瘤肿瘤生长速率。尽管肿瘤生长不需要宿主瘦素，但瘦素可加速黑色素瘤的生长。
Epidemiological studies suggest that obesity increases the risk of developing several cancers, including melanoma. Obesity increases the expression of angiogenic factors, such as leptin, that may contribute to tumor growth. However, a direct cause and effect relationship between obesity and tumor growth has not been clearly established and the role of leptin in accelerating tumor growth is unclear. Our objective in the present study was to examine the rate of melanoma tumor growth in lean and obese mice with leptin deficiency or high levels of plasma leptin. We injected 1 × 10 B16F10 melanoma cells subcutaneously into lean wild type (WT), obese melanocortin receptor 4 knockout (MC4R−/−), which have high leptin levels, obese leptin-deficient(ob −/−), pair fed lean ob−/−, and lean ob+/− mice. Mean body weights were 29.7 ± 0.3 g (WT), 46.3 ± 1.9 g (MC4R−/−), 63.7 ± 0.9 g (ob−/−), 30.5 ± 1.0 g (pair fed ob−/−) and 31.6 ± 1.7 g (ob+/−). Tumors were much larger in the obese leptin deficientob−/− (5.1 ± 0.9 g) and obese MC4R−/− (5.1 ± 0.7 g) than in lean WT (1.9 ± 0.3 g) and ob+/− (2.8 ± 0.7 g) mice. prevention of obesity by pair feeding ob−/− mice dramatically reduced tumor weight (0.95 ± 0.2 g) to a level that was significantly lower than in WT mice of the same weight. Tumor VEGF levels were the highest in the obese mouse tumors (p < 0.05), regardless of the host leptin levels. Except for the lean ob+/−, MC4R−/− and ob−/− melanomas had the highest VEGF receptor 1 and VEGF receptor 2 protein expression (p < 0.01 and p < 0.05), respectively. These results indicate that obesity markedly increases melanoma tumor growth rate by mechanisms that may involve upregulation of VEGF pathways. although tumor growth does not require host leptin, melanoma tumor growth may be accelerated by leptin.
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影响因子：
120.7
作者：
Flegal, KM;Carroll, MD;Johnson, CL
通讯作者：
Johnson, CL
肥胖可促进雌性扎克大鼠蒽诱导的乳腺肿瘤发育的7,12-二甲基苯子。
DOI：
10.1186/bcr1263
发表时间：
2005
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Hakkak R;Holley AW;Macleod SL;Simpson PM;Fuchs GJ;Jo CH;Kieber-Emmons T;Korourian S
通讯作者：
Korourian S
影响因子：
56.9
作者：
Sierra-Honigmann, MR;Nath, AK;Flores-Riveros, JR
通讯作者：
Flores-Riveros, JR
影响因子：
20.1
作者：
Bouloumié, A;Drexler, HCA;Busse, R
通讯作者：
Busse, R
影响因子：
4.9
作者：
Cleary, MP;Grande, JP;Maihle, NJ
通讯作者：
Maihle, NJ