Patterns of growth, axonal extension and axonal arborization of neuronal lineages in the developing Drosophila brain.
Patterns of growth, axonal extension and axonal arborization of neuronal lineages in the developing Drosophila brain.
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DOI：
10.1016/j.ydbio.2009.06.015
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发表时间：
2009-11-15
影响因子：
2.7
通讯作者：
Hartenstein, Volker
中科院分区：
文献类型：
--
作者：
Larsen, Camilla;Shy, Diana;Spindler, Shana R.;Fung, Siaumin;Pereanu, Wayne;Younossi-Hartenstein, Amelia;Hartenstein, Volker
果蝇的中央脑由大约100对谱系组成，大多数谱系由100-150个神经元组成。大多数血统都有一些共同的重要特征。通常，一个谱系的神经元作为一个连贯的簇保持在一起，并将它们的轴突投射成从胚胎晚期到成年可见的连贯束。在胚胎时期出生的神经元形成初级轴突束（PAT），其遵循神经堆中的定型通路。在孵化时，凋亡性细胞死亡平均去除30-40%的原代神经元。在幼虫期产生的次级神经元形成次级轴突束（SAT），其通常与其相应的初级轴突束成束状。SAT发育成连接成人大脑不同区域的长神经束。在结构上，我们区分三种类型的谱系：PD谱系，其特征在于不同的，空间上分离的近端和远端分支; C谱系分支连续沿着其道的整个长度分布; D谱系缺乏近端分支。许多谱系的分支，特别是PD型的分支，仅限于不同的神经堆隔室。我们认为，隔间是由个别血统或其小团体“脚手架”。因此，每个初级谱系的初级神经元数量相对较少，从而在晚期胚胎中建立了隔室图。在幼虫期，皮层的增长仅仅是通过初级神经元的乔木体积的增加。次生神经元的乔木内或附近的幼虫车厢，导致更小的车厢细分和额外的，成人特定的车厢。
The Drosophila central brain is composed of approximately 100 paired lineages, with most lineages comprising 100–150 neurons. Most lineages have a number of important characteristics in common. Typically, neurons of a lineage stay together as a coherent cluster and project their axons into a coherent bundle visible from late embryo to adult. Neurons born during the embryonic period form the primary axon tracts (PATs) that follow stereotyped pathways in the neuropile. Apoptotic cell death removes an average of 30–40% of primary neurons around the time of hatching. Secondary neurons generated during the larval period form secondary axon tracts (SATs) that typically fasciculate with their corresponding primary axon tract. SATs develop into the long fascicles that interconnect the different compartments of the adult brain. Structurally, we distinguish between three types of lineages: PD lineages, characterized by distinct, spatially separate proximal and distal arborizations; C lineages with arborizations distributed continuously along the entire length of their tract; D lineages that lack proximal arborizations. Arborizations of many lineages, in particular those of the PD type, are restricted to distinct neuropile compartments. We propose that compartments are ‘scaffolded” by individual lineages, or small groups thereof. Thereby, the relatively small number of primary neurons of each primary lineage set up the compartment map in the late embryo. Compartments grow during the larval period simply by an increase in arbor volume of primary neurons. Arbors of secondary neurons form within or adjacent to the larval compartments, resulting in smaller compartment subdivisions and additional, adult specific compartments.
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影响因子：
11.4
作者：
DELAESCALERA, S;BOCKAMP, EO;JIMENEZ, F
通讯作者：
JIMENEZ, F
影响因子：
16.2
作者：
Bello, BC;Hirth, F;Gould, AP
通讯作者：
Gould, AP
影响因子：
2.7
作者：
ITO, K;HOTTA, Y
通讯作者：
HOTTA, Y
影响因子：
2.5
作者：
Dumstrei, K;Wang, F;Hartenstein, V
通讯作者：
Hartenstein, V
DOI：
10.1007/978-0-387-78261-4_9
发表时间：
2008-01-01
期刊：
BRAIN DEVELOPMENT IN DROSOPHILA MELANOGRASTER
影响因子：
--
作者：
Ito, Kei;Awasaki, Takeshi
通讯作者：
Awasaki, Takeshi