Endogenous amdoparvovirus-related elements reveal insights into the biology and evolution of vertebrate parvoviruses.
Endogenous amdoparvovirus-related elements reveal insights into the biology and evolution of vertebrate parvoviruses.
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DOI：
10.1093/ve/vey026
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发表时间：
2018-07
期刊：
影响因子：
5.3
通讯作者：
Gifford RJ
中科院分区：
文献类型：
--
作者：
Pénzes JJ;Marsile-Medun S;Agbandje-McKenna M;Gifford RJ
Amdoparvoviruses (family Parvoviridae: genus Amdoparvovirus) infect carnivores, and are a major cause of morbidity and mortality in farmed animals. In this study, we systematically screened animal genomes to identify endogenous parvoviral elements (EPVs) disclosing a high degree of similarity to amdoparvoviruses, and investigated their genomic, phylogenetic and protein structural features. We report the first examples of full-length, amdoparvovirus-derived EPVs in the genome of the Transcaucasian mole vole (Ellobius lutescens). We also identify four EPVs in mammal and reptile genomes that are intermediate between amdoparvoviruses and their sister genus (Protoparvovirus) in terms of their phylogenetic placement and genomic features. In particular, we identify a genome-length EPV in the genome of a pit viper (Protobothrops mucrosquamatus) that is more similar to a protoparvovirus than an amdoparvovirus in terms of its phylogenetic placement and the structural features of its capsid protein (as revealed by homology modeling), yet exhibits characteristically amdoparvovirus-like genome features including: (1) a putative middle ORF gene; (2) a capsid gene that lacks a phospholipase A2 domain; (3) a genome structure consistent with an amdoparvovirus-like mechanism of capsid gene expression. Our findings indicate that amdoparvovirus host range extends to rodents, and that parvovirus lineages possessing a mixture of proto- and amdoparvovirus-like characteristics have circulated in the past. In addition, we show that EPV sequences in the mole vole and pit viper encode intact, expressible replicase genes that have potentially been co-opted or exapted in these host species.
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影响因子：
5.9
作者：
Huang LY;Halder S;Agbandje-McKenna M
通讯作者：
Agbandje-McKenna M
DOI：
10.3390/v10040143
发表时间：
2018-03-22
期刊：
Viruses
影响因子：
--
作者：
de Souza WM;Dennis T;Fumagalli MJ;Araujo J;Sabino-Santos G;Maia FGM;Acrani GO;Carrasco AOT;Romeiro MF;Modha S;Vieira LC;Ometto T;Queiroz LH;Durigon EL;Nunes MRT;Figueiredo LTM;Gifford RJ
通讯作者：
Gifford RJ
影响因子：
30.3
作者：
Holmes EC
通讯作者：
Holmes EC
影响因子：
5.4
作者：
Belyi, Vladimir A.;Levine, Arnold J.;Skalka, Anna Marie
通讯作者：
Skalka, Anna Marie
影响因子：
1.4
作者：
Abdala, F;Hancox, PJ;Neveling, J
通讯作者：
Neveling, J