Evaluation of piperonyl butoxide in enhancing the efficacy of pyrethroid insecticides against resistant Anopheles gambiae s.l. in Ghana.
Evaluation of piperonyl butoxide in enhancing the efficacy of pyrethroid insecticides against resistant Anopheles gambiae s.l. in Ghana.
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DOI：
10.1186/s12936-017-1960-3
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发表时间：
2017-08-17
期刊：
影响因子：
3
通讯作者：
Boakye DA
中科院分区：
文献类型：
--
作者：
Dadzie SK;Chabi J;Asafu-Adjaye A;Owusu-Akrofi O;Baffoe-Wilmot A;Malm K;Bart-Plange C;Coleman S;Appawu MA;Boakye DA
使用拟除虫菊酯的疟疾病媒控制方法仍然是加纳用于防治疟疾病媒的战略。这些方法包括在加纳许多地区使用长效驱虫蚊帐和室内滞留喷洒。然而，有证据表明，对拟除虫菊酯的抗药性在加纳许多地区普遍存在。增效剂已被证明可用于抑制负责抗性发展的酶，并因此增强冈比亚按蚊（Anopheles gambiae sensu lato（s.l.）在许多领域。本研究探讨了胡椒基丁醚（PBO）对铜绿假单胞菌敏感性的影响。冈比亚公司在加纳的一些哨点。三到五天大的安。冈比亚公司在WHO药敏试管试验中使用从幼虫饲养的小鼠。每批20 - 25只雌成虫。冈比亚有限公司同时暴露于单独的杀虫剂和PBO+杀虫剂。记录60 min后的击倒率和24 h的死亡率。按蚊对溴氰菊酯和氯菊酯的抗性。冈比亚公司在2015年和2016年在所有地点都观察到了这种情况。溴氰菊酯暴露后24小时的死亡率范围为16.3%（Weija）至82.3%（Kade），而氯菊酯暴露后24小时的死亡率范围为3.8%（Gomoa Obuasi）至91.3%（Prestea）。在2015年和2016年期间，在大多数地点观察到对溴氰菊酯的敏感性显著增加，对二氯苯醚菊酯的敏感性减少。冈比亚有限公司蚊子预先暴露于PBO。本研究的结果表明，PBO的使用显着增加了AN的易感性。冈比亚公司在大部分的监控地点发现蚊子。建议将PBO作为杀虫剂的媒介控制策略在存在溴氰菊酯和氯菊酯抗性的情况下可有效杀灭蚊子。
Malaria vector control methods involving the use of pyrethroids remain the strategies being used against malaria vectors in Ghana. These methods include the use of long-lasting insecticidal nets and indoor residual spraying in many areas in Ghana. However, there is evidence that pyrethroid resistance is widespread in many areas in Ghana. Synergists have been shown to be useful in inhibiting the enzymes that are responsible for the development of resistance and hence enhance the insecticide susceptibility of Anopheles gambiae sensu lato (s.l.) in many areas. The present study investigated the effect of piperonyl butoxide (PBO) on the susceptibility status of An. gambiae s.l. across some sentinel sites in Ghana. Three to five day old An. gambiae s.l. reared from larvae were used in WHO susceptibility tube assays. Batches of 20–25 female adult An. gambiae s.l. were exposed simultaneously to the insecticide alone and to the PBO + insecticide. The knock down rate after 60 min and mortality at 24 h were recorded. Deltamethrin and permethrin resistance of An. gambiae s.l. was observed in all the sites in 2015 and 2016. The mortality after 24 h post exposure for deltamethrin ranged from 16.3% in Weija to 82.3% in Kade, whereas that for permethrin ranged from 3.8% in Gomoa Obuasi to 91.3% in Prestea. A significant increase in susceptibility to deltamethrin and less to permethrin was observed during both 2015 and 2016 years in most of the sites when An. gambiae s.l. mosquitoes were pre-exposed to PBO. Findings from this study showed that the use of PBO significantly enhanced the susceptibility of An. gambiae s.l. mosquitoes in most of the sentinel sites. It is recommended that vector control strategies incorporating PBO as a synergist can be effective in killing mosquitoes in the presence of deltamethrin and permethrin resistance.
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影响因子：
3
作者：
Kleinschmidt I;Mnzava AP;Kafy HT;Mbogo C;Bashir AI;Bigoga J;Adechoubou A;Raghavendra K;Knox TB;Malik EM;Nkuni ZJ;Bayoh N;Ochomo E;Fondjo E;Kouambeng C;Awono-Ambene HP;Etang J;Akogbeto M;Bhatt R;Swain DK;Kinyari T;Njagi K;Muthami L;Subramaniam K;Bradley J;West P;Massougbodji A;Okê-Sopoh M;Hounto A;Elmardi K;Valecha N;Kamau L;Mathenge E;Donnelly MJ
通讯作者：
Donnelly MJ
影响因子：
3.2
作者：
Hunt RH;Fuseini G;Knowles S;Stiles-Ocran J;Verster R;Kaiser ML;Choi KS;Koekemoer LL;Coetzee M
通讯作者：
Coetzee M
DOI：
10.1016/s0140-6736(15)00417-1
发表时间：
2016-04-23
期刊：
Lancet (London, England)
影响因子：
--
作者：
Hemingway J;Ranson H;Magill A;Kolaczinski J;Fornadel C;Gimnig J;Coetzee M;Simard F;Roch DK;Hinzoumbe CK;Pickett J;Schellenberg D;Gething P;Hoppé M;Hamon N
通讯作者：
Hamon N
影响因子：
56.3
作者：
Corbel, Vincent;Akogbeto, Martin;Henry, Marie-Claire
通讯作者：
Henry, Marie-Claire
影响因子：
3.2
作者：
Chabi, Joseph;Baidoo, Philip K.;Diclaro, Joseph W., II
通讯作者：
Diclaro, Joseph W., II