Self-folding devices and materials for biomedical applications.

Self-folding devices and materials for biomedical applications.
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DOI:
10.1016/j.tibtech.2011.06.013
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发表时间:
2012-03
影响因子:
17.3
通讯作者:
Gracias, David H.
Gracias, David H.
中科院分区:
工程技术1区
文献类型:
--
作者:
Randall, Christina L.;Gultepe, Evin;Gracias, David H.

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由于天然细胞环境是三维(3D)的,因此需要将平面、微米和纳米结构的生物医学器件扩展到第三维。自折叠方法可以将平面光刻图案化的精度扩展到第三维,并创建响应于特定环境线索而折叠或展开的可重构结构。在这里,我们回顾了使用铰链为基础的自折叠方法在创建功能的3D生物医学设备,包括精确图案化的纳米到厘米级多面体容器,细胞培养支架,和可重构的手术工具,如夹具,自主响应特定的化学品。
Since the native cellular environment is three dimensional (3D), there is a need to extend planar, micro and nanostructured biomedical devices to the third dimension. Self-folding methods can extend the precision of planar lithographic patterning into the third dimension and create reconfigurable structures that fold or un-fold in response to specific environmental cues. Here, we review the use of hinge-based self-folding methods in the creation of functional 3D biomedical devices including precisely patterned nano to centimeter scale polyhedral containers, scaffolds for cell culture, and reconfigurable surgical tools such as grippers that respond autonomously to specific chemicals.
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