Major structural differences and novel potential virulence mechanisms from the genomes of multiple campylobacter species.
Major structural differences and novel potential virulence mechanisms from the genomes of multiple campylobacter species.
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DOI：
10.1371/journal.pbio.0030015
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发表时间：
2005-01
期刊：
影响因子：
9.8
通讯作者：
Nelson KE
中科院分区：
文献类型：
--
作者：
Fouts DE;Mongodin EF;Mandrell RE;Miller WG;Rasko DA;Ravel J;Brinkac LM;DeBoy RT;Parker CT;Daugherty SC;Dodson RJ;Durkin AS;Madupu R;Sullivan SA;Shetty JU;Ayodeji MA;Shvartsbeyn A;Schatz MC;Badger JH;Fraser CM;Nelson KE
4株弯曲杆菌的基因组序列测定和比较分析。lari RM2100、C. upsaliensis RM 3195和C. coli RM 2228的研究揭示了与噬菌体和质粒样基因组岛的插入相关的主要结构差异，以及脂寡糖复合物的主要变化。Poly G纤维束较长，数量较多，并且在C中显示出更大的变异性。upsaliensis比在其他物种。许多参与宿主定植的基因，包括racR/S、cadF、cdt、ciaB和鞭毛蛋白基因，在物种间是保守的，但对于脂寡糖位点、荚膜（细胞外）多糖位点和新的弯曲杆菌推定的licABCD毒力位点，似乎是物种特异性的变异是明显的。这些菌株的代谢特征以及对一系列抗生素的耐药性特征也各不相同。很明显，新发现的假设和保守的假设蛋白质，以及未表征的双组分调控系统和膜蛋白，可能持有额外的重要信息，物种之间的毒力的主要差异，以及特定宿主的菌株的特异性。虽然人类空肠弯曲菌的单一基因组序列提供了一些见解，但对同一属的多个物种的比较阐明了对毒力机制的更大理解
Sequencing and comparative genome analysis of four strains of Campylobacter including C. lari RM2100, C. upsaliensis RM3195, and C. coli RM2228 has revealed major structural differences that are associated with the insertion of phage- and plasmid-like genomic islands, as well as major variations in the lipooligosaccharide complex. Poly G tracts are longer, are greater in number, and show greater variability in C. upsaliensis than in the other species. Many genes involved in host colonization, including racR/S, cadF, cdt, ciaB, and flagellin genes, are conserved across the species, but variations that appear to be species specific are evident for a lipooligosaccharide locus, a capsular (extracellular) polysaccharide locus, and a novel Campylobacter putative licABCD virulence locus. The strains also vary in their metabolic profiles, as well as their resistance profiles to a range of antibiotics. It is evident that the newly identified hypothetical and conserved hypothetical proteins, as well as uncharacterized two-component regulatory systems and membrane proteins, may hold additional significant information on the major differences in virulence among the species, as well as the specificity of the strains for particular hosts. Although the single genome sequence of the human Campylobacter jejuni yielded some insight, comparison of multiple species of the same genus elucidated greater understanding of virulence mechanisms
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DOI：
10.1073/pnas.1932838100
发表时间：
2003-09-30
影响因子：
11.1
作者：
Baar, C;Eppinger, M;Schuster, SC
通讯作者：
Schuster, SC
影响因子：
14.9
作者：
Biery, MC;Stewart, FJ;Craig, NL
通讯作者：
Craig, NL
影响因子：
14.9
作者：
Gajer, P;Schatz, M;Salzberg, SL
通讯作者：
Salzberg, SL
影响因子：
64.8
作者：
Alm, RA;Ling, LSL;Trost, TJ
通讯作者：
Trost, TJ
DOI：
10.1073/pnas.152298499
发表时间：
2002-07-23
影响因子：
11.1
作者：
Beres, SB;Sylva, GL;Musser, JM
通讯作者：
Musser, JM