Time to progression from discoid lupus erythematosus to systemic lupus erythematosus: a retrospective cohort study.

Time to progression from discoid lupus erythematosus to systemic lupus erythematosus: a retrospective cohort study.
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DOI:
10.1111/ced.14014
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发表时间:
2020-01
影响因子:
4.1
通讯作者:
Merola JF
Merola JF
中科院分区:
医学4区
文献类型:
--
作者:
Elman SA;Joyce C;Costenbader KH;Merola JF

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确定诊断为DLE的患者进展为SLE的风险以及这种风险的时间范围是重要的临床问题。过去的报告显示,从DLE进展为SLE的时间范围较宽,平均进展时间约为8年。使用从学术狼疮中心获得的数据,我们确定了32例从DLE进展为SLE的患者。在我们的队列中,我们发现从DLE进展到SLE的中位时间为453天,比以前报道的要快得多。我们相信这些信息可以帮助临床医生监测访视间隔以及如何最好地为SLE患者提供咨询。
Determining the risk of progression to SLE among patients diagnosed with DLE, and the time frame of this risk, are important clinical questions. Past reports have demonstrated a wide time frame of progression from DLE to SLE, with mean time to progression of approximately eight years. Using data obtained from an academic lupus center, we identified 32 patients who progressed from DLE to SLE. In our cohort, we found that the median time to progression from DLE to SLE was 453 days, much sooner than previously reported. We believe this information can help inform clinicians on monitoring visit intervals as well as how best to counsel patients on SLE progression.
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