Milk Macrophage Function in Bovine Leukemia Virus-Infected Dairy Cows.
Milk Macrophage Function in Bovine Leukemia Virus-Infected Dairy Cows.
复制标题
DOI：
10.3389/fvets.2021.650021
复制
发表时间：
2021
影响因子：
3.2
通讯作者：
de Souza FN
中科院分区：
文献类型：
--
作者：
Lima ES;Blagitz MG;Batista CF;Alves AJ;Fernandes ACC;Ramos Sanchez EM;Frias Torres H;Diniz SA;Silva MX;Della Libera AMMP;de Souza FN
牛白血病病毒（BLV）对先天性和获得性免疫反应的影响已被广泛研究，然而，BLV对乳腺免疫的影响需要进一步研究。本研究调查的活力，吞噬能力，和细胞内生产的活性氧和氮物种（RONS）的巨噬细胞在牛奶样品中自然感染BLV与持续性淋巴细胞增多症（PL）或不。BLV感染对每毫升巨噬细胞总数和活巨噬细胞在总乳活细胞中的百分比没有影响。此外，BLV感染的奶牛有更高频率的活乳巨噬细胞，而健康动物有倾向于更高百分比的凋亡乳巨噬细胞。血清阴性奶牛乳巨噬细胞吞噬金黄色葡萄球菌的比例高于BLV感染奶牛。未观察到BLV感染对乳巨噬细胞胞内RONS产生和吞噬强度的影响。因此，这项研究提供了新的见解BLV感染的牛乳腺的影响。
The implications of bovine leukemia virus (BLV) on innate and adaptive immune responses have been widely investigated; however, the effects of BLV on mammary gland immunity require further investigation. The present study investigated the viability, phagocytic capacity, and intracellular production of reactive oxygen and nitrogen species (RONS) by macrophages in milk samples from dairy cows naturally infected with BLV with or without persistent lymphocytosis (PL). No effect of BLV infection in the overall number of macrophages per milliliter and in the percentage of viable macrophages among overall milk viable cells was found. Furthermore, BLV-infected dairy cows had a higher frequency of viable milk macrophages, while healthy animals had a tendency toward a higher percentage of apoptotic milk macrophages. The percentage of milk macrophages that phagocytosed Staphylococcus aureus in seronegative animals was higher than that in BLV-infected dairy cows. No effect of BLV infection on the intracellular RONS production and the intensity of phagocytosis by milk macrophages was observed. Thus, this study provides new insights into the implications of BLV infections in the bovine mammary gland.
登录
查看更多内容
DOI：
10.1253/circj.cj-16-0924
发表时间：
2016-10-25
期刊：
Circulation journal : official journal of the Japanese Circulation Society
影响因子：
--
作者：
Linton MF;Babaev VR;Huang J;Linton EF;Tao H;Yancey PG
通讯作者：
Yancey PG
影响因子：
3.7
作者：
Cuesta, Lucia Martinez;Liron, Juan Pedro;Ceriani, Maria Carolina
通讯作者：
Ceriani, Maria Carolina
影响因子：
0.2
作者：
de Almeida, Italo Camara;Hatum de Almeida, Sayanne Luns;Di Filippo, Paula Alessandra
通讯作者：
Di Filippo, Paula Alessandra
影响因子：
3.8
作者：
Doménech, A;Goyache, J;Gómez-Lucía, E
通讯作者：
Gómez-Lucía, E
影响因子：
158.5
作者：
JOHNSTON, RB
通讯作者：
JOHNSTON, RB