Improved Functional Outcome After Peripheral Nerve Stimulation of the Impaired Forelimb Post-stroke.
Improved Functional Outcome After Peripheral Nerve Stimulation of the Impaired Forelimb Post-stroke.
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DOI：
10.3389/fneur.2021.610434
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发表时间：
2021
影响因子：
3.4
通讯作者：
Nockels RP
中科院分区：
文献类型：
--
作者：
Tsai SY;Schreiber JA;Adamczyk NS;Wu JY;Ton ST;Hofler RC;Walter JS;O'Brien TE;Kartje GL;Nockels RP
大脑供血不足，即，缺血性中风导致神经细胞的损失，并因此导致受影响的脑区域的功能丧失。除了在最初的几个小时内恢复血液流动外，没有有效的治疗方法来改善失去的功能。康复策略被广泛使用，但成效有限。本研究旨在探讨电刺激对中风后上肢功能恢复的影响。我们开发了一种啮齿动物模型，使用电极袖植入到麻痹前肢的单个外周神经（正中神经）上，并每天施加电刺激。采用熟练前肢伸展试验评价脑卒中和电刺激后的功能结局。用生物素化葡聚糖胺从第V层锥体神经元进行顺行轴突追踪，以评估从对侧病变皮层到去传入脊髓的新神经元连接的形成。接受正中神经电刺激的大鼠在熟练的前肢伸展测试中与仅中风和假刺激中风相比显示出显著的改善。接受电刺激的大鼠也表现出显着改善的潜伏期，以启动粘合剂从受损的前肢，表明更好的感觉恢复。此外，轴突追踪分析显示，接受电刺激的大鼠颈髓中线纤维交叉指数显著升高。我们的研究结果表明，直接周围神经刺激导致改善感觉运动恢复中风受损的前肢，并可能是一个有用的方法，以改善中风后的赤字在人类患者。
Lack of blood flow to the brain, i.e., ischemic stroke, results in loss of nerve cells and therefore loss of function in the effected brain regions. There is no effective treatment to improve lost function except restoring blood flow within the first several hours. Rehabilitation strategies are widely used with limited success. The purpose of this study was to examine the effect of electrical stimulation on the impaired upper extremity to improve functional recovery after stroke. We developed a rodent model using an electrode cuff implant onto a single peripheral nerve (median nerve) of the paretic forelimb and applied daily electrical stimulation. The skilled forelimb reaching test was used to evaluate functional outcome after stroke and electrical stimulation. Anterograde axonal tracing from layer V pyramidal neurons with biotinylated dextran amine was done to evaluate the formation of new neuronal connections from the contralesional cortex to the deafferented spinal cord. Rats receiving electrical stimulation on the median nerve showed significant improvement in the skilled forelimb reaching test in comparison with stroke only and stroke with sham stimulation. Rats that received electrical stimulation also exhibited significant improvement in the latency to initiate adhesive removal from the impaired forelimb, indicating better sensory recovery. Furthermore, axonal tracing analysis showed a significant higher midline fiber crossing index in the cervical spinal cord of rats receiving electrical stimulation. Our results indicate that direct peripheral nerve stimulation leads to improved sensorimotor recovery in the stroke-impaired forelimb, and may be a useful approach to improve post-stroke deficits in human patients.
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影响因子：
8.3
作者：
Jones TA;Allred RP;Adkins DL;Hsu JE;O'Bryant A;Maldonado MA
通讯作者：
Maldonado MA
影响因子：
24
作者：
Elgendy, Islam Y.;Kumbhani, Dharam J.;Bavry, Anthony A.
通讯作者：
Bavry, Anthony A.
影响因子：
3.4
作者：
Kamper, DG;Rymer, WZ
通讯作者：
Rymer, WZ
DOI：
10.1016/j.pmr.2015.06.002
发表时间：
2015-11
影响因子：
1.7
作者：
Knutson JS;Fu MJ;Sheffler LR;Chae J
通讯作者：
Chae J
影响因子：
2.1
作者：
BERTELLI, JA;TALEB, M;PECOTDECHAVASSINE, M
通讯作者：
PECOTDECHAVASSINE, M