Fish consumption and risk of stroke and its subtypes: accumulative evidence from a meta-analysis of prospective cohort studies.
Fish consumption and risk of stroke and its subtypes: accumulative evidence from a meta-analysis of prospective cohort studies.
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DOI：
10.1038/ejcn.2012.133
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发表时间：
2012-11
影响因子：
4.7
通讯作者：
He K
中科院分区：
文献类型：
--
作者：
Xun P;Qin B;Song Y;Nakamura Y;Kurth T;Yaemsiri S;Djousse L;He K
为了提供一个可靠的评估的假设关联的鱼类消费与中风的风险累积，更新荟萃分析发表的前瞻性队列研究进行。选择截至2012年4月在MEDLINE和EMBASE中检索的同行评审期刊中的前瞻性队列研究。通过Google或检索相关文章中的参考文献列表检索到更多信息。主要的结果测量是加权风险比（HR）和相应的95%置信区间（CI）的中风事件根据鱼类消费使用随机效应模型。数据库来自16项符合条件的研究（19个队列），包括402127例患者（10568例事件病例），平均随访时间为12.8年。与从不吃鱼或吃鱼<1/月的人相比，总卒中风险的合并校正HR为0.97（95% CI，0.87-1.08），0.86（0.80-0.93）、0.91（0.85-0.98）和0.87（0.79-0.96）（P线性趋势= 0.09; P非线性趋势= 0.02）。研究地点是一个修正因素。鱼类摄入量和中风发病率之间的负相关性仅在北美进行的研究中发现。缺血性卒中患者的中度负相关性更明显，出血性卒中患者的中度负相关性减弱。从这项荟萃分析中积累的证据表明，鱼类摄入量可能对中风，特别是缺血性中风的风险具有保护作用。
To provide a reliable assessment of the hypothesized association of fish consumption with stroke risk accumulatively, an updated meta-analysis of published prospective cohort studies was conducted. Prospective cohort studies through April 2012 in peer-reviewed journals indexed in MEDLINE and EMBASE were selected. Additional information was retrieved through Google or a search of the reference list in relevant articles. The main outcome measure was the weighted hazards ratio (HR) and corresponding 95% confidence interval (CI) for incident stroke according to fish consumption using a random-effects model. A database was derived from 16 eligible studies (19 cohorts), including 402 127 individuals (10 568 incident cases) with an average 12.8 years of follow-up. Compared with those who never consumed fish or ate fish <1/month, the pooled adjusted HRs of total stroke risk were 0.97 (95% CI, 0.87–1.08), 0.86 (0.80–0.93), 0.91 (0.85–0.98) and 0.87 (0.79–0.96) for those who consumed fish 1–3/month, 1/week, 2–4/week and ≥5/week, respectively (Plinear trend = 0.09; Pnonlinear trend = 0.02). Study location was a modifier. An inverse association between fish intake and stroke incidence was only found by studies conducted in North America. The modest inverse associations were more pronounced with ischemic stroke and were attenuated with hemorrhagic stroke. Accumulated evidence generated from this meta-analysis suggests that fish intake may have a protective effect against the risk of stroke, particularly ischemic stroke.
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影响因子：
--
作者：
Mozaffarian, D;Longstreth, WT;Siscovick, DS
通讯作者：
Siscovick, DS
影响因子：
5.9
作者：
Nakamura, Y;Ueshima, H;Okayama, A
通讯作者：
Okayama, A
影响因子：
8.3
作者：
Orencia, AJ;Daviglus, ML;Stamler, J
通讯作者：
Stamler, J
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
120.7
作者：
He, K;Rimm, EB;Ascherio, A
通讯作者：
Ascherio, A