Solvent-free Fabrication of Tissue Engineering Scaffolds with Immiscible Polymer Blends.
Solvent-free Fabrication of Tissue Engineering Scaffolds with Immiscible Polymer Blends.
复制标题
DOI：
10.1080/00914037.2013.854222
复制
发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Li W
中科院分区：
文献类型：
--
作者：
Ma L;Jiang W;Li W
以不相容的聚乳酸和蔗糖共混物为原料，通过气体发泡和水浸出的方法制备了一种完全有机无溶剂的组织工程支架。制备了孔隙率大于90%、孔径为25~200μm的聚乳酸支架。通过控制挤出温度和发泡工艺参数等工艺参数，可以控制材料的孔径和孔隙率。动态力学分析表明，挤出温度可以用来控制支架的强度。分别用无泡沫和泡沫支架培养人胶质母细胞瘤(GBM)细胞M059K。结果表明，细胞在发泡的聚乳酸支架中生长良好。该方法具有较强的通用性，可用于无残留有机溶剂的组织工程支架的制备。
A completely organic solvent-free fabrication method is developed for tissue engineering scaffolds by gas foaming of immiscible polylactic acid (PLA) and sucrose blends, followed by water leaching. PLA scaffolds with above 90% porosity and 25–200 μm pore size were fabricated. The pore size and porosity was controlled with process parameters including extrusion temperature and foaming process parameters. Dynamic mechanical analysis showed that the extrusion temperature could be used to control the scaffold strength. Both unfoamed and foamed scaffolds were used to culture glioblastoma (GBM) cells M059K. The results showed that the cells grew better in the foamed PLA scaffolds. The method presented in the paper is versatile and can be used to fabricate tissue engineering scaffolds without any residual organic solvents.
登录
查看更多内容
影响因子：
3.9
作者：
Das, S;Hollister, SJ;Widjaja, E
通讯作者：
Widjaja, E
DOI：
10.1002/jbm.820270207
发表时间：
1993-02-01
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
--
作者：
MIKOS, AG;BAO, Y;LANGER, R
通讯作者：
LANGER, R
影响因子：
14
作者：
Nam, YS;Park, TG
通讯作者：
Park, TG
DOI：
10.1073/pnas.0308463100
发表时间：
2004-02-24
影响因子：
11.1
作者：
Dmitrieva, NI;Cai, Q;Burg, MB
通讯作者：
Burg, MB
影响因子：
14
作者：
Cai, Q;Yang, JA;Wang, SG
通讯作者：
Wang, SG