Association between arsenic exposure from drinking water and plasma levels of soluble cell adhesion molecules.
Association between arsenic exposure from drinking water and plasma levels of soluble cell adhesion molecules.
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DOI：
10.1289/ehp.10277
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发表时间：
2007-10
影响因子：
10.4
通讯作者：
Ahsan H
中科院分区：
文献类型：
--
作者：
Chen Y;Santella RM;Kibriya MG;Wang Q;Kappil M;Verret WJ;Graziano JH;Ahsan H
在暴露于各种砷水平的人群中进行心血管疾病危险因素和适当生物标志物的流行病学研究是公共卫生研究的优先事项。我们调查了孟加拉国Araihazar的砷暴露人群中，饮用水中无机砷暴露与血浆可溶性细胞间粘附分子-1（sICAM-1）和可溶性血管粘附分子-1（sVCAM-1）水平之间的关系，这两种细胞间粘附分子-1（sICAM-1）和可溶性血管粘附分子-1（sVCAM-1）均为内皮功能障碍和血管炎症的标志物。研究参与者包括115名患有砷相关皮肤病变的个体，他们参加了一项2 × 2随机、安慰剂对照、双盲的维生素E和硒补充试验。在基线和随访6个月后评估砷暴露状态和血浆sICAM-1和sVCAM-1水平。基线井砷，砷暴露的长期措施，与基线水平的sICAM-1和sVCAM-1，并随着时间的推移，这两个标志物的变化呈正相关。基线时，砷浓度每增加1 μg/L，血浆sICAM-1和sVCAM-1分别增加0.10 ng/mL [95%置信区间（CI），0.00-0.20]和0.33 ng/mL（95% CI，0.15-0.51）。尽管在研究期间尿砷以及维生素E和硒的补充最近发生了变化，但从基线到随访，井水砷每增加1 μg/L，sICAM-1和sVCAM-1分别增加0.11 ng/mL（95%CI，0.01-0.22）和0.17 ng/mL（95%CI，0.00-0.35）。研究结果表明，饮用水中的慢性砷暴露对血管炎症的影响随着时间的推移而持续存在，并且还表明砷暴露与心血管疾病之间存在潜在的相关机制。
Epidemiologic studies of cardiovascular disease risk factors and appropriate biomarkers in populations exposed to a wide range of arsenic levels are a public health research priority. We investigated the relationship between inorganic arsenic exposure from drinking water and plasma levels of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular adhesion molecule-1 (sVCAM-1), both markers of endothelial dysfunction and vascular inflammation, in an arsenic-exposed population in Araihazar, Bangladesh. The study participants included 115 individuals with arsenic-related skin lesions participating in a 2 × 2 randomized, placebo-controlled, double-blind trial of vitamin E and selenium supplementation. Arsenic exposure status and plasma levels of sICAM-1 and sVCAM-1 were assessed at baseline and after 6 months of follow-up. Baseline well arsenic, a long-term measure of arsenic exposure, was positively associated with baseline levels of both sICAM-1 and sVCAM-1 and with changes in the two markers over time. At baseline, for every 1-μg/L increase in well arsenic there was an increase of 0.10 ng/mL [95% confidence interval (CI), 0.00–0.20] and 0.33 ng/mL (95% CI, 0.15–0.51) in plasma sICAM-1 and sVCAM-1, respectively. Every 1-μg/L increase in well arsenic was associated with a rise of 0.11 ng/mL (95% CI, 0.01–0.22) and 0.17 ng/mL (95% CI, 0.00–0.35) in sICAM-1 and sVCAM-1 from baseline to follow-up, respectively, in spite of recent changes in urinary arsenic as well as vitamin E and selenium supplementation during the study period. The findings indicate an effect of chronic arsenic exposure from drinking water on vascular inflammation that persists over time and also suggest a potential mechanism underlying the association between arsenic exposure and cardiovascular disease.
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影响因子：
8.3
作者：
CHEN, CJ;HSUEH, YM;TAI, TY
通讯作者：
TAI, TY
影响因子：
4.8
作者：
Griffin, RJ;Lee, SH;Song, CW
通讯作者：
Song, CW
影响因子：
5.6
作者：
Hou, YC;Hsu, CS;Yeh, SL
通讯作者：
Yeh, SL
影响因子：
3.8
作者：
Flower, L;Ahuja, RH;Mohamed-Ali, V
通讯作者：
Mohamed-Ali, V
DOI：
10.1038/sj.jea.7500449
发表时间：
2006-03-01
影响因子：
4.5
作者：
Ahsan, H;Chen, Y;Graziano, J
通讯作者：
Graziano, J