Pubertal recalibration of cortisol reactivity following early life stress: a cross-sectional analysis.
Pubertal recalibration of cortisol reactivity following early life stress: a cross-sectional analysis.
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DOI：
10.1111/jcpp.12992
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发表时间：
2019-05
期刊：
影响因子：
--
通讯作者：
Gunnar MR
中科院分区：
文献类型：
--
作者：
DePasquale CE;Donzella B;Gunnar MR
从孤儿院或其他此类机构收养的儿童往往对压力源表现出迟钝的反应，即使在到达普遍支持和资源丰富的收养后家庭多年后也是如此。青春期是环境对压力调节系统影响的敏感时期，可能为离开机构的儿童提供一个机会，根据他们现在更具支持性的生活状况重新调整压力反应系统。这项横断面研究检查了 280 名 7 至 14 岁儿童的 HPA 轴反应性； 122 名儿童被收养于 14 个国家的机构，年龄在 6 个月至 5 岁之间，平均 95% 的生命是在机构照料中度过的，而 158 名在其亲生家庭中具有类似较高社会经济地位的儿童作为非收养对照组。护士对所有儿童进行了坦纳阶段评估，并在不同的一天完成了特里尔儿童社会压力测试。使用线性混合效应模型和唾液皮质醇的 7 项测量结果表明，与非收养儿童相比，青春期早期的机构化儿童表现出较弱的 HPA 轴反应性，但青春期中/晚期的机构化儿童表现出与非收养儿童相似的较高反应性。这是首个证据表明，在被收容后的儿童中，HPA 轴对心理社会压力源的反应可能在青春期重新校准，这为未来关于收养后环境的保护因素以及随后的生理、行为和心理病理结果的研究提供了一个有希望的途径。
Children adopted from orphanages or other such institutions tend to display blunted reactivity to stressors - even years after arriving in their generally supportive and highly resourced postadoption homes. Puberty, a proposed sensitive period for environmental influences on stress-mediating systems, may provide an opportunity for post-institutionalized children to recalibrate stress response systems in accordance with their now more supportive living situations. This cross-sectional study examined the HPA-axis reactivity of 280 children ages 7 through 14 years; 122 children were adopted from institutions in 14 countries between the ages of 6 months and 5 years, after spending an average of 95% of their lives in institutional care, and 158 children of similarly high socioeconomic status in their biological families served as the nonadopted comparison group. All of the children were assessed by nurses for Tanner stage and, on a different day, completed the Trier Social Stress Test for Children. Using a linear mixed-effects model and 7 measures of salivary cortisol, results indicated that early-pubertal post-institutionalized children showed blunted HPA-axis reactivity compared to nonadopted children, but mid/late-pubertal post-institutionalized children displayed higher reactivity similar to the nonadopted comparison children. This is the first evidence of possible pubertal recalibration of HPA axis reactivity to a psychosocial stressor in post-institutionalized children, which provides a promising avenue for future research regarding the protective factors of the postadoption environment and subsequent physiological, behavioral, and psychopathological outcomes.
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影响因子：
3.3
作者：
Eiland, L.;Romeo, R. D.
通讯作者：
Romeo, R. D.
DOI：
10.1001/archpediatrics.2010.54
发表时间：
2010-05-01
影响因子：
--
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Bethea, Cynthia L.
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影响因子：
8.2
作者：
Del Giudice, Marco;Ellis, Bruce J.;Shirtcliff, Elizabeth A.
通讯作者：
Shirtcliff, Elizabeth A.
影响因子：
3.7
作者：
Granger, Douglas A.;Hibel, Leah C.;Kapelewski, Christine H.
通讯作者：
Kapelewski, Christine H.