TNFAIP8 as a predictor of metastasis and a novel prognostic biomarker in patients with epithelial ovarian cancer.
TNFAIP8 as a predictor of metastasis and a novel prognostic biomarker in patients with epithelial ovarian cancer.
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DOI：
10.1038/bjc.2013.501
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发表时间：
2013-09-17
影响因子：
8.8
通讯作者：
Yin, H.
中科院分区：
文献类型：
--
作者：
Liu, T.;Gao, H.;Chen, X.;Lou, G.;Gu, L.;Yang, M.;Xia, B.;Yin, H.
肿瘤坏死因子-α-诱导蛋白8（TNFAIP 8）最近已被证明在各种恶性肿瘤中，但其在上皮性卵巢癌（EOC）中的作用仍不清楚。实时荧光定量逆转录PCR和Western blot检测肿瘤坏死因子-α诱导蛋白8的表达。收集了202例接受原发性细胞减灭术的EOC患者（国际妇产科医师联合会I-IV）的肿瘤组织，包括浆液性、粘液性、类浆液性和透明细胞组织型。通过免疫组化方法检测TNFAIP 8的表达，并探讨其临床意义。肿瘤坏死因子-α诱导蛋白8的过度表达与高组织学分级（P=0.005）、大残留肿瘤大小（P=0.014）、复发（P=0.024）和对化疗的反应（P<0.001）显著相关。多因素分析显示TNFAIP 8过表达与淋巴结转移（OR：4.129; 95%CI：1.491-11.435; P=0.006）和腹腔转移（OR：2.209; 95%CI：1.174-4.156; P=0.014）独立相关。此外，结果显示，TNFAIP 8表达状态是EOC患者的癌症特异性生存期（风险比（HR）：1.852; 95%CI：1.322-2.594; P<0.001）和无病生存期（HR：1.724; 95%CI：1.235-2.407; P=0.001）的独立预后因素。目前的数据提供了TNFAIP 8预测EOC转移和较差存活的证据，突出了其作为EOC治疗靶标的潜在功能。
Tumour necrosis factor-α-induced protein 8 (TNFAIP8) has been recently documented in various malignancies, but its role in epithelial ovarian cancer (EOC) remains unknown. Tumour necrosis factor-α-induced protein 8 expression was determined by real-time reverse transcription PCR and western blot analysis. Tumour tissues, consisting of serous, mucinous, endometrioid and clear cell histotypes, from 202 EOC patients (International Federation of Gynecologists and Obstetricians I–IV) who underwent primary cytoreduction were collected. Then, we examined the immunohistochemical expression of TNFAIP8 and evaluated its clinical significances. Tumour necrosis factor-α-induced protein 8 overexpression was significantly associated with high histologic grade (P=0.005), large residual tumour size (P=0.014), recurrence (P=0.024) and response to chemotherapy (P<0.001). Multivariate analysis showed that TNFAIP8 overexpression was independently correlated with the presence of lymph node (odds ratio (OR): 4.129; 95% confidence interval (CI): 1.491–11.435; P=0.006) and intraperitoneal metastasis (OR: 2.209; 95% CI: 1.174–4.156; P=0.014). Moreover, results revealed that the status of TNFAIP8 expression was an independently prognostic factor for both cancer-specific survival (hazard ratio (HR): 1.852; 95% CI: 1.322–2.594; P<0.001) and disease-free survival (HR: 1.724; 95% CI: 1.235–2.407; P=0.001) in patients with EOC. The present data provide evidence that TNFAIP8 predicts EOC metastasis and poor survival, highlighting its potential function as a therapeutic target for EOCs.
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