Application of platelet-rich plasma with stem cells in bone and periodontal tissue engineering.
Application of platelet-rich plasma with stem cells in bone and periodontal tissue engineering.
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DOI：
10.1038/boneres.2016.36
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发表时间：
2016
期刊：
影响因子：
12.7
通讯作者：
Yang, Shuying
中科院分区：
文献类型：
--
作者：
Fernandes, Gabriela;Yang, Shuying
目前，在美国和世界范围内，骨移植物非常缺乏。由于目前对骨移植物的需求和导致骨丢失的疾病数量的增加，再生骨是首要关注的问题。自体骨是目前骨再生的金标准。然而，缺点如供体部位发病率和可用性降低限制了其使用。即使同种异体移植物和合成移植材料也有其自身的局限性。由于某些特定的干细胞可以在生长因子（GF）的存在下定向分化成成骨细胞谱系，因此干细胞成为骨再生的理想试剂。此外，富含血小板的血浆（PRP），它可以很容易地从全血中分离，通常用于骨再生，伤口愈合和骨缺损修复。当干细胞与PRP在GF存在下结合时，它们能够促进骨生成。本文综述了干细胞和PRP在体外、体内的应用及其在未来临床研究中的应用。
Presently, there is a high paucity of bone grafts in the United States and worldwide. Regenerating bone is of prime concern due to the current demand of bone grafts and the increasing number of diseases causing bone loss. Autogenous bone is the present gold standard of bone regeneration. However, disadvantages like donor site morbidity and its decreased availability limit its use. Even allografts and synthetic grafting materials have their own limitations. As certain specific stem cells can be directed to differentiate into an osteoblastic lineage in the presence of growth factors (GFs), it makes stem cells the ideal agents for bone regeneration. Furthermore, platelet-rich plasma (PRP), which can be easily isolated from whole blood, is often used for bone regeneration, wound healing and bone defect repair. When stem cells are combined with PRP in the presence of GFs, they are able to promote osteogenesis. This review provides in-depth knowledge regarding the use of stem cells and PRP in vitro, in vivo and their application in clinical studies in the future.
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