The Potential Roles of Blood-Brain Barrier and Blood-Cerebrospinal Fluid Barrier in Maintaining Brain Manganese Homeostasis.
The Potential Roles of Blood-Brain Barrier and Blood-Cerebrospinal Fluid Barrier in Maintaining Brain Manganese Homeostasis.
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DOI：
10.3390/nu13061833
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发表时间：
2021-05-27
期刊：
影响因子：
5.9
通讯作者：
Zhao N
中科院分区：
文献类型：
--
作者：
McCabe SM;Zhao N
锰（Mn）是生命所必需的微量营养素，但在大脑中高浓度时会产生神经毒性。大脑是一个“特权”器官，主要通过两个屏障与全身血液循环分开。脑内的内皮细胞形成紧密连接并充当血脑屏障（BBB），其物理地将循环血液与脑实质分离。在血液和脑脊液（CSF）之间是脉络丛（CP），它是一种充当血液-脑脊液屏障（BCB）的组织。体循环中的药物、蛋白质和金属不能到达大脑和脊髓，除非通过两个脑屏障中的任何一个。BBB和BCB由紧密连接的细胞组成，这些细胞发挥神经保护的关键作用，并控制脑环境和血液循环之间的物质交换。许多最近的出版物提供了在体内或在细胞模型中的锰转运的见解。本文就脑内锰代谢的研究进展作一综述，并探讨血脑屏障和血脑屏障在维持脑内锰稳态中的作用。
Manganese (Mn) is a trace nutrient necessary for life but becomes neurotoxic at high concentrations in the brain. The brain is a “privileged” organ that is separated from systemic blood circulation mainly by two barriers. Endothelial cells within the brain form tight junctions and act as the blood–brain barrier (BBB), which physically separates circulating blood from the brain parenchyma. Between the blood and the cerebrospinal fluid (CSF) is the choroid plexus (CP), which is a tissue that acts as the blood–CSF barrier (BCB). Pharmaceuticals, proteins, and metals in the systemic circulation are unable to reach the brain and spinal cord unless transported through either of the two brain barriers. The BBB and the BCB consist of tightly connected cells that fulfill the critical role of neuroprotection and control the exchange of materials between the brain environment and blood circulation. Many recent publications provide insights into Mn transport in vivo or in cell models. In this review, we will focus on the current research regarding Mn metabolism in the brain and discuss the potential roles of the BBB and BCB in maintaining brain Mn homeostasis.
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影响因子：
5.7
作者：
Aoki, I;Wu, YJL;Koretsky, AP
通讯作者：
Koretsky, AP
影响因子：
3.7
作者：
Bosomworth HJ;Adlard PA;Ford D;Valentine RA
通讯作者：
Valentine RA
影响因子：
64.5
作者：
BORGSTAHL, GEO;PARGE, HE;TAINER, JA
通讯作者：
TAINER, JA
影响因子：
2.9
作者：
Bock, Nicholas A.;Paiva, Fernando F.;Silva, Afonso C.
通讯作者：
Silva, Afonso C.
DOI：
10.1111/j.1749-6632.1986.tb27146.x
发表时间：
1986-12-30
影响因子：
5.2
作者：
BRADBURY, MWB
通讯作者：
BRADBURY, MWB