Endometriosis and infertility: a review of the pathogenesis and treatment of endometriosis-associated infertility.
Endometriosis and infertility: a review of the pathogenesis and treatment of endometriosis-associated infertility.
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DOI：
10.1016/j.ogc.2012.10.002
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发表时间：
2012-12
影响因子：
3.2
通讯作者：
Taylor HS
中科院分区：
文献类型：
--
作者：
Macer ML;Taylor HS
子宫内膜异位症与不孕症有关，但其影响生育的机制尚不完全清楚。本文综述了子宫内膜异位症的发病机制、对生育的影响以及子宫内膜异位症相关不孕症的治疗。病因学理论包括月经逆行、体腔化生、免疫改变、干细胞和遗传学。子宫内膜异位症影响配子和胚胎、输卵管和胚胎运输以及异位子宫内膜；这些异常都可能影响生育能力。目前子宫内膜异位症相关不孕症的治疗方案包括手术、人工授精超排卵和体外受精。我们还讨论了子宫内膜异位症相关不孕的潜在治疗方法，如干细胞移植和免疫治疗。
Endometriois has been associated with infertility, however the mechanism by which it affects fertility are still not fully understood. This manuscript reviews the proposed mechanisms of endometriosis pathogenesis, it affects on fertility and treatments of endometriosis-associated infertility. Theories on etiology of disease include retrograde menstruation, coelomic metaplasia, altered immunity, stem cells, and genetics. Endometriosis affects gametes and embryos, the fallopian tubes and embryo transport, and the eutopic endometrium; these abnormalities likely all impact fertility. Current treatment options of endometriosis-associated infertility include surgery, superovulation with IUI, and IVF. We also discuss potential future treatments for endometriosis related infertility such as stem cells transplantation and immune therapy.
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影响因子：
82.9
作者：
Dinulescu, DM;Ince, TA;Jacks, T
通讯作者：
Jacks, T
影响因子：
6.7
作者：
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通讯作者：
Maheux, R
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通讯作者：
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