Emerging microtechnologies for the development of oral drug delivery devices.
Emerging microtechnologies for the development of oral drug delivery devices.
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DOI：
10.1016/j.addr.2012.08.013
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发表时间：
2012-11
影响因子：
16.1
通讯作者：
Desai, Tejal A.
中科院分区：
文献类型：
--
作者：
Chirra, Hariharasudhan D.;Desai, Tejal A.
关键词：
开发用于以安全有效的方式跨胃肠上皮施用治疗剂的口服药物递送平台是非常重要的。已经开发了多种递送系统，例如肠溶包衣片剂、胶囊、颗粒和脂质体，以改善药物的口服生物利用度。然而，口服给药的药物由于各种生理条件如低pH和高剪切肠液流而具有较差的定位和治疗功效。结合控释、改善的粘附性、组织渗透和选择性肠靶向的新型平台可以克服这些问题，并潜在地减少与常规口服递送相关的毒性和高施用频率。微加工沿着适当的表面化学，提供了一种制造这些平台的方法，该方法在定制微型装置的形状、尺寸、储存器体积和表面特性方面具有灵活性。此外，相同的技术可用于包括集成电路技术和传感器，用于设计复杂的自主药物递送装置，其有望显著改善护理点诊断和治疗医学应用。这篇评论揭示了一些制造技术，并解决了一些微制造设备，可以有效地用于控制口服药物输送应用。
The development of oral drug delivery platforms for administering therapeutics in a safe and effective manner across the gastrointestinal epithelium is of much importance. A variety of delivery systems such as enterically coated tablets, capsules, particles, and liposomes have been developed to improve oral bioavailability of drugs. However, orally administered drugs suffer from poor localization and therapeutic efficacy due to various physiological conditions such as low pH, and high shear intestinal fluid flow. Novel platforms combining controlled release, improved adhesion, tissue penetration, and selective intestinal targeting may overcome these issues and potentially diminish the toxicity and high frequency of administration associated with conventional oral delivery. Microfabrication along with appropriate surface chemistry, provide a means to fabricate these platforms en masse with flexibility in tailoring the shape, size, reservoir volume, and surface characteristics of microdevices. Moreover, the same technology can be used to include integrated circuit technology and sensors for designing sophisticated autonomous drug delivery devices that promise to significantly improve point of care diagnostic and therapeutic medical applications. This review sheds light on some of the fabrication techniques and addresses a few of the microfabricated devices that can be effectively used for controlled oral drug delivery applications.
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