A population MRI brain template and analysis tools for the macaque.

A population MRI brain template and analysis tools for the macaque.
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DOI:
10.1016/j.neuroimage.2017.04.063
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发表时间:
2018-04-15
期刊:
影响因子:
5.7
通讯作者:
Messinger A
Messinger A
中科院分区:
医学1区
文献类型:
--
作者:
Seidlitz J;Sponheim C;Glen D;Ye FQ;Saleem KS;Leopold DA;Ungerleider L;Messinger A

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标准解剖模板的使用在人类神经成像中很常见,因为它有助于跨受试者和研究的数据分析和比较。对于非人类灵长类动物,以前的体内模板缺乏足够的对比度来可靠地验证已知的解剖学大脑区域,并且没有提供用于自动化单个受试者处理的工具。在这里,我们提出了“国家心理健康研究所猕猴模板”,或简称NMT。NMT是从31名受试者生成的平均猕猴大脑的高分辨率体内MRI模板,以及用于改进数据分析和可视化的神经成像工具。从NMT体积中,我们生成了组织分割和皮质厚度的图。表面重建和转换到以前出版的数字大脑图谱也提供了。我们还提供了一个使用NMT的分析管道,该管道自动化并简化了针对个体受试者的解剖扫描的大脑提取、组织分割和形态特征估计的耗时过程。因此,NMT和相关工具为精确的单受试者数据分析以及跨受试者和研究的神经成像结果特征提供了一个通用平台。
The use of standard anatomical templates is common in human neuroimaging, as it facilitates data analysis and comparison across subjects and studies. For non-human primates, previous in vivo templates have lacked sufficient contrast to reliably validate known anatomical brain regions and have not provided tools for automated single-subject processing. Here we present the “National Institute of Mental Health Macaque Template”, or NMT for short. The NMT is a high-resolution in vivo MRI template of the average macaque brain generated from 31 subjects, as well as a neuroimaging tool for improved data analysis and visualization. From the NMT volume, we generated maps of tissue segmentation and cortical thickness. Surface reconstructions and transformations to previously published digital brain atlases are also provided. We further provide an analysis pipeline using the NMT that automates and standardizes the time-consuming processes of brain extraction, tissue segmentation, and morphometric feature estimation for anatomical scans of individual subjects. The NMT and associated tools thus provide a common platform for precise single-subject data analysis and for characterizations of neuroimaging results across subjects and studies.
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