Mapping of an endogenous retroviral sequence to human chromosome 18
Mapping of an endogenous retroviral sequence to human chromosome 18
复制标题
内源逆转录病毒序列与人类 18 号染色体的映射
作者：
S. O’Brien;T. Bonner;Maurice Cohen;C. O'Connell;W. Nash
重组DNA技术的应用使得在人类基因组中检测到至少三个与先前从小鼠和灵长类动物中分离的逆转录病毒同源的中等重复的DNA片段1-3。通过核苷酸序列比较，其中一个DNA片段与Moloney鼠白血病病毒(MoMuLV)和内源性狒狒逆转录病毒(MoMuLV)有较远的亲缘关系，并具有整合型逆转录病毒的序列组织特征。从黑猩猩DNA中分离出同源基因，表明整合事件发生在黑猩猩和人类进化分化之前。在这里，我们使用了一组啮齿动物与人类体细胞杂交的方法，将这一片段的染色体定位称为ERV1(内源性逆转录病毒-1)，定位于人类18号染色体(HSA18)。
The application of recombinant DNA technologies has allowed the detection of at least three families of moderately repetitive DNA segments in the human genome that are homologous to retroviruses previously isolated from mice and primates1–3. One of these DNA segments has been shown2 by nucleotide sequence comparisons to be distantly related to both Moloney murine leukaemia virus (MoMuLV) and the endogenous baboon retrovirus and to have the sequence organization characteristic of an integrated retrovirus. Isolation of the homologous locus from chimpanzee DNA indicated that the integration event preceded the evolutionary divergence of chimpanzees and man. Here we have used a panel of rodent × human somatic cell hybrids to assign the chromosomal localization of this segment, called ERV1 (endogenous retrovirus-1), to human chromosome 18 (HSA 18).
猫肉瘤病毒和禽成髓细胞瘤病毒 onc 基因的人类同源物的染色体分配。
DOI：
10.1073/pnas.79.15.4714
发表时间：
1982
影响因子：
11.1
作者：
Dalla-Favera,R;Franchini,G;Martinotti,S;Wong-Staal,F;Gallo,RC;Croce,CM
通讯作者：
Croce,CM
DOI：
10.1073/pnas.79.24.7824
发表时间：
1982-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
DALLAFAVERA, R;BREGNI, M;CROCE, CM
通讯作者：
CROCE, CM
影响因子：
158.5
作者：
YUNIS, JJ;OKEN, MM;THEOLOGIDES, A
通讯作者：
THEOLOGIDES, A