The shared risk of diabetes between dog and cat owners and their pets: register based cohort study.
The shared risk of diabetes between dog and cat owners and their pets: register based cohort study.
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DOI：
10.1136/bmj.m4337
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发表时间：
2020-12-10
期刊：
影响因子：
--
通讯作者：
Kennedy B
中科院分区：
文献类型：
--
作者：
Delicano RA;Hammar U;Egenvall A;Westgarth C;Mubanga M;Byberg L;Fall T;Kennedy B
调查狗和猫的主人和他们的宠物是否有患糖尿病的风险。队列研究。基于登记册的纵向研究，瑞典。在基线评估期内(2004年1月1日至2006年12月31日)确定了208对 980主人-狗和123对 566主人-猫。猫狗主人的2型糖尿病事件和其宠物的糖尿病事件，包括在随访期(2007年1月1日至2012年12月31日)期间的诊断日期。通过结合国家患者登记、死亡原因登记和瑞典处方药登记中的信息，确定了患有2型糖尿病的所有者。关于宠物糖尿病的信息是从兽医护理保险数据中提取的。多状态模型被用来以95%的可信区间评估风险比，并调整可能的共同风险因素，包括个人和社会经济情况。随访期2型糖尿病发病率，狗主人为7.7例/1000人年，猫主人为7.9例/1000人年。宠物的糖尿病发病率为每1000年患病狗1.3例，每1000猫年患病2.2例。有糖尿病的狗主人与没有糖尿病的狗主人相比，2型糖尿病的粗略危险比为1.38(95%可信区间为1.10至1.74)，多变量调整后的危险比为1.32(1.04至1.68)。拥有患有2型糖尿病的主人会增加狗患糖尿病的风险(粗风险比1.28，1.01至1.63)，在调整主人的年龄后，风险有所减弱，可信区间超过零(1.11，0.87至1.42)。没有发现猫主人的2型糖尿病和他们的猫的糖尿病之间的关联(粗风险比分别为0.99，0.74到1.34和1.00，0.78到1.28)。数据显示，与没有糖尿病的狗的主人相比，患有糖尿病的狗的主人在随访期间更有可能患上2型糖尿病。患有糖尿病的狗有可能成为共同的糖尿病致病健康行为和环境暴露的哨兵。
To investigate whether dog and cat owners and their pets share a risk of developing diabetes. Cohort study. Register based longitudinal study, Sweden. 208 980 owner-dog pairs and 123 566 owner-cat pairs identified during a baseline assessment period (1 January 2004 to 31 December 2006). Type 2 diabetes events in dog and cat owners and diabetes events in their pets, including date of diagnosis during the follow-up period (1 January 2007 to 31 December 2012). Owners with type 2 diabetes were identified by combining information from the National Patient Register, the Cause of Death Register, and the Swedish Prescribed Drug Register. Information on diabetes in the pets was extracted from veterinary care insurance data. Multi-state models were used to assess the hazard ratios with 95% confidence intervals and to adjust for possible shared risk factors, including personal and socioeconomic circumstances. The incidence of type 2 diabetes during follow-up was 7.7 cases per 1000 person years at risk in dog owners and 7.9 cases per 1000 person years at risk in cat owners. The incidence of diabetes in the pets was 1.3 cases per 1000 dog years at risk and 2.2 cases per 1000 cat years at risk. The crude hazard ratio for type 2 diabetes in owners of a dog with diabetes compared with owners of a dog without diabetes was 1.38 (95% confidence interval 1.10 to 1.74), with a multivariable adjusted hazard ratio of 1.32 (1.04 to 1.68). Having an owner with type 2 diabetes was associated with an increased hazard of diabetes in the dog (crude hazard ratio 1.28, 1.01 to 1.63), which was attenuated after adjusting for owner’s age, with the confidence interval crossing the null (1.11, 0.87 to 1.42). No association was found between type 2 diabetes in cat owners and diabetes in their cats (crude hazard ratio 0.99, 0.74 to 1.34, and 1.00, 0.78 to 1.28, respectively). Data indicated that owners of a dog with diabetes were more likely to develop type 2 diabetes during follow-up than owners of a dog without diabetes. It is possible that dogs with diabetes could serve as a sentinel for shared diabetogenic health behaviours and environmental exposures.
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影响因子：
16.2
作者：
Chiang JL;Kirkman MS;Laffel LM;Peters AL;Type 1 Diabetes Sourcebook Authors
通讯作者：
Type 1 Diabetes Sourcebook Authors
影响因子：
0.8
作者：
Bonnett, B. N.;Egenvall, A.
通讯作者：
Egenvall, A.
影响因子：
2.6
作者：
Fall, T.;Hedhammar, A.;Kampe, O.
通讯作者：
Kampe, O.
影响因子：
2.6
作者：
Fall, Tove;Hamlin, Helene Hansson;Egenvall, Agneta
通讯作者：
Egenvall, Agneta
影响因子：
2.6
作者：
Bjornvad, C. R.;Gloor, S.;Lund, T. B.
通讯作者：
Lund, T. B.