Malnutrition: Percentage and Association with Prognosis in Patients Hospitalized for Coronavirus Disease 2019.
Malnutrition: Percentage and Association with Prognosis in Patients Hospitalized for Coronavirus Disease 2019.
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营养不良：2019冠状病毒病住院患者中的比例及其与预后的关联
DOI：
10.3390/nu12123679
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发表时间：
2020-11-28
期刊：
影响因子：
5.9
通讯作者：
Cosson E
中科院分区：
文献类型：
--
作者：
Allard L;Ouedraogo E;Molleville J;Bihan H;Giroux-Leprieur B;Sutton A;Baudry C;Josse C;Didier M;Deutsch D;Bouchaud O;Cosson E
先前的研究已发现营养不良与呼吸道感染的预后之间存在相关性。我们的目的是确定（i）营养不良的百分比，以及（ii）2019冠状病毒病（COVID - 19）入院患者的营养不良预后情况。在这项单中心回顾性研究中，我们连续纳入了2020年4月9日至5月29日期间所有患有急性COVID - 19的成年患者。营养不良通过低体重指数（BMI）以及过去一个月体重减轻≥5%和/或过去六个月体重减轻≥10%来诊断。营养风险指数（NRI）定义了营养风险。重症COVID - 19定义为需要鼻导管吸氧≥6 L/min。我们招募了108名患者（64名男性，年龄62 ± 16岁，BMI为28.8 ± 6.2 kg/m²），其中34名（31.5%）患有重症COVID - 19。42名（38.9%）患者存在营养不良，83名（84.7%）患者存在中度或重度营养风险。营养不良与COVID - 19的严重程度无关。营养风险与重症COVID - 19相关（p < 0.01；在校正C反应蛋白后p < 0.01），血浆蛋白、白蛋白、前白蛋白和锌水平较低也与之相关（p < 0.01）。营养不良的主要原因是炎症。营养不良的高比例以及营养风险与COVID - 19预后之间的关联支持了国际指南中关于必要时进行定期筛查和营养支持的建议。
Previous studies have found a correlation between malnutrition and prognosis in respiratory infections. Our objectives were to determine (i) the percentage of malnutrition, and (ii) its prognosis in patients admitted for coronavirus disease 2019 (COVID-19). In this monocentric retrospective study, we consecutively included all adult patients presenting with acute COVID-19 between 9 April and 29 May 2020. Malnutrition was diagnosed on low body mass index (BMI) and weight loss ≥ 5% in the previous month and/or ≥ 10% in the previous six months. The Nutritional Risk Index (NRI) defined nutritional risk. Severe COVID-19 was defined as a need for nasal oxygen ≥ 6 L/min. We enrolled 108 patients (64 men, 62 ± 16 years, BMI 28.8 ± 6.2 kg/m2), including 34 (31.5%) with severe COVID-19. Malnutrition was found in 42 (38.9%) patients, and moderate or severe nutritional risk in 83 (84.7%) patients. Malnutrition was not associated with COVID-19 severity. Nutritional risk was associated with severe COVID-19 (p < 0.01; p < 0.01 after adjustment for C reactive protein), as were lower plasma proteins, albumin, prealbumin, and zinc levels (p < 0.01). The main cause of malnutrition was inflammation. The high percentage of malnutrition and the association between nutritional risk and COVID-19 prognosis supports international guidelines advising regular screening and nutritional support when necessary.
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影响因子：
5.9
作者：
Junaid K;Ejaz H;Abdalla AE;Abosalif KOA;Ullah MI;Yasmeen H;Younas S;Hamam SSM;Rehman A
通讯作者：
Rehman A
影响因子：
4.2
作者：
Chandra, Ranjit Kumar;Kumari, Sobha
通讯作者：
Kumari, Sobha
DOI：
10.1002/jpen.2036
发表时间：
2021-01
期刊：
JPEN. Journal of parenteral and enteral nutrition
影响因子：
--
作者：
Mechanick JI;Carbone S;Dickerson RN;Hernandez BJD;Hurt RT;Irving SY;Li DY;McCarthy MS;Mogensen KM;Gautier JBO;Patel JJ;Prewitt TE;Rosenthal M;Warren M;Winkler MF;McKeever L;ASPEN COVID-19 Task Force on Nutrition Research
通讯作者：
ASPEN COVID-19 Task Force on Nutrition Research
影响因子：
4.7
作者：
Liu, Gaoli;Zhang, Shaowen;Hu, Haifeng
通讯作者：
Hu, Haifeng
影响因子：
8.9
作者：
Phung, D. T.;Wang, Z.;Chu, C.
通讯作者：
Chu, C.