SARS-CoV-2 in Danish Mink Farms: Course of the Epidemic and a Descriptive Analysis of the Outbreaks in 2020.
SARS-CoV-2 in Danish Mink Farms: Course of the Epidemic and a Descriptive Analysis of the Outbreaks in 2020.
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DOI：
10.3390/ani11010164
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发表时间：
2021-01-12
期刊：
影响因子：
--
通讯作者：
Bøtner A
中科院分区：
文献类型：
--
作者：
Boklund A;Hammer AS;Quaade ML;Rasmussen TB;Lohse L;Strandbygaard B;Jørgensen CS;Olesen AS;Hjerpe FB;Petersen HH;Jensen TK;Mortensen S;Calvo-Artavia FF;Lefèvre SK;Nielsen SS;Halasa T;Belsham GJ;Bøtner A
自2019年以来，SARS-CoV-2疫情蔓延，成为全球大流行。出乎意料的是，2020年4月，荷兰检测到养殖水貂感染SARS-CoV-2，6月，丹麦三个水貂养殖场检测到感染。当时丹麦大约有1140个水貂养殖场，从9月份开始，感染水貂的养殖场数量迅速增加。对这些农场的感染特征进行了检查，并评估了农场之间可能的传播途径。显然，这种感染很容易在养殖场内的水貂之间传播，并可以在与养殖水貂有密切接触的人之间传播。感染在彼此靠近的农场之间传播，但直接人类接触仍然是唯一已确定的病毒传播途径。SARS-CoV-2感染是人类感染新冠肺炎的原因。2020年4月，荷兰发生养殖水貂SARS-CoV-2感染(新视觉)。丹麦的第一批疫情于2020年6月在三个农场发现。从9月份开始，受感染农场的数量急剧增加。在这里，我们描述了从215个受感染的水貂养殖场收集的流行数据，以表征疾病在受感染养殖场的传播和影响。在三分之一的农场，没有观察到临床症状。在有临床症状的养殖场，在有限的时间内(中位数为11天)，最常见的是饲料摄入量减少、死亡率增加和呼吸道症状。在65%和69%的养殖场中，第一次抽样的动物中分别有100%检测到病毒和血清转换。SARS-CoV-2病毒在水貂附近、水貂皮毛、苍蝇、海鸥脚和地沟水中低水平采集的空气样本中检测到，但在饲料中检测不到。来自受感染农场的一些狗和猫的病毒检测呈阳性。在几个农场采集的鸡、兔和马的样本，以及在受感染农场附近采样的野生动物的SARS-CoV-2检测均未呈阳性。因此，水貂非常容易感染SARS-CoV-2，但除了直接人类接触外，农场之间的传播途径尚不清楚。
Since 2019, SARS-CoV-2 has spread and become a global pandemic. Unexpectedly, infection of farmed mink by SARS-CoV-2 was detected in the Netherlands in April 2020 and infections in three mink farms in Denmark were detected in June. Approximately 1140 mink farms were present in Denmark at the time, and a rapid increase in the number of farms with infected mink occurred from September onwards. Features of the infection on these farms were examined and potential routes of transmission between farms evaluated. It is apparent that the infection spread very easily between mink within a farm and can spread to and from people with close contact to the farmed mink. The infection spread between farms in close proximity to each other, but direct human contact is still the only identified route of virus transmission. SARS-CoV-2 infection is the cause of COVID-19 in humans. In April 2020, SARS-CoV-2 infection in farmed mink (Neovision vision) occurred in the Netherlands. The first outbreaks in Denmark were detected in June 2020 in three farms. A steep increase in the number of infected farms occurred from September and onwards. Here, we describe prevalence data collected from 215 infected mink farms to characterize spread and impact of disease in infected farms. In one third of the farms, no clinical signs were observed. In farms with clinical signs, decreased feed intake, increased mortality and respiratory symptoms were most frequently observed, during a limited time period (median of 11 days). In 65% and 69% of farms, virus and sero-conversion, respectively, were detected in 100% of sampled animals at the first sampling. SARS-CoV-2 was detected, at low levels, in air samples collected close to the mink, on mink fur, on flies, on the foot of a seagull, and in gutter water, but not in feed. Some dogs and cats from infected farms tested positive for the virus. Chickens, rabbits, and horses sampled on a few farms, and wildlife sampled in the vicinity of the infected farms did not test positive for SARS-CoV-2. Thus, mink are highly susceptible to infection by SARS-CoV-2, but routes of transmission between farms, other than by direct human contact, are unclear.
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DOI：
10.1126/science.abe5901
发表时间：
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