LAPTM4B: an oncogene in various solid tumors and its functions.
LAPTM4B: an oncogene in various solid tumors and its functions.
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发现了癌基因Lysosome-associated protein transmembrane-4β（LAPTM 4 B）基因，并证实该基因5′-UTR多态性与肿瘤易感性相关。LAPTM 4 B-35蛋白在多种实体瘤中高表达，可能是一种预后不良的标志物。同时探讨了LAPTM 4 B在实体瘤中的功能。提示LAPTM 4 B可促进肿瘤细胞增殖、增强侵袭转移、抗凋亡、启动自噬和协助耐药。
The oncogene Lysosome-associated protein transmembrane-4β (LAPTM4B) gene was identified, and the polymorphism region in the 5′-UTR of this gene was certified to be associated with tumor susceptibility. LAPTM4B-35 protein was found to be highly expressed in various solid tumors and could be a poor prognosis marker. The functions of LAPTM4B in solid tumors were also explored. It is suggested that LAPTM4B could promote the proliferation of tumor cells, boost invasion and metastasis, resist apoptosis, initiate autophagy and assist drug resistance.
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