Sex and age differences in COVID-19 mortality in Europe.

Sex and age differences in COVID-19 mortality in Europe.
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DOI:
10.1007/s00508-020-01793-9
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发表时间:
2021-04
影响因子:
2.6
通讯作者:
Lindahl-Jacobsen R
Lindahl-Jacobsen R
中科院分区:
医学4区
文献类型:
--
作者:
Ahrenfeldt LJ;Otavova M;Christensen K;Lindahl-Jacobsen R

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研究欧洲不同年龄组和地区2019冠状病毒病(COVID-19)生存率的性别差异程度。我们假设,在任何年龄,男性的死亡率都高于女性,但性别差异会随着年龄的增长而减少,因为只有最健康的男性才能活到更老的年龄。我们使用了来自National institute D ' Études dmographiques的人口数据,分析了2020年2月至6月期间欧洲10个地区因COVID-19导致的累积死亡人数:丹麦、挪威、瑞典、荷兰、英格兰和威尔士、法国、德国、意大利、西班牙和葡萄牙。对于每个地区,我们计算了按年龄和性别分层的累积死亡率,以及相应的男性与女性的相对风险。在所有地区几乎所有年龄组中,男性死于COVID-19的相对风险都高于女性。总体相对危险度范围从葡萄牙的1.11(95%可信区间,CI 1.01-1.23)到法国的1.54 (95% CI 1.49-1.58)。在大多数地区,性别差异在60-69岁之前有所增加,之后逐渐减少,在80岁以上时性别差异最小。尽管不同地区的数据收集和时间覆盖存在差异,但该研究显示,欧洲COVID-19死亡率的总体性别差异模式相似。本文的在线版本(10.1007/s00508-020-01793-9)包含补充资料,仅供授权用户使用。
To examine the magnitude of sex differences in survival from the coronavirus disease 2019 (COVID-19) in Europe across age groups and regions. We hypothesized that men have a higher mortality than women at any given age but that sex differences will decrease with age as only the healthiest men survive to older ages. We used population data from the Institut National D’Études Démographiques on cumulative deaths due to COVID-19 from February to June 2020 in 10 European regions: Denmark, Norway, Sweden, The Netherlands, England and Wales, France, Germany, Italy, Spain and Portugal. For each region, we calculated cumulative mortality rates stratified by age and sex and corresponding relative risks for men vs. women. The relative risk of dying from COVID-19 was higher for men than for women in almost all age groups in all regions. The overall relative risk ranged from 1.11 (95% confidence interval, CI 1.01–1.23) in Portugal to 1.54 (95% CI 1.49–1.58) in France. In most regions, sex differences increased until the ages of 60–69 years, but decreased thereafter with the smallest sex difference at age 80+ years. Despite variability in data collection and time coverage among regions, the study showed an overall similar pattern of sex differences in COVID-19 mortality in Europe. The online version of this article (10.1007/s00508-020-01793-9) contains supplementary material, which is available to authorized users.
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