Responses of simultaneously recorded respiratory-related medullary neurons to stimulation of multiple sensory modalities.
Responses of simultaneously recorded respiratory-related medullary neurons to stimulation of multiple sensory modalities.
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同时记录的呼吸相关髓质神经元对多种感觉方式刺激的反应。
DOI：
10.1152/jn.1999.82.1.176
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Lindsey,BG
中科院分区：
文献类型：
--
作者：
Li,Z;Morris,KF;Baekey,DM;Shannon,R;Lindsey,BG
这项研究提出的假设是，多个传入系统共享一个分布式脑干网络的元素，该网络调节呼吸运动模式。数据来自18只去大脑、双侧迷走神经切断、瘫痪、人工呼吸机的猫。用微电极阵列同时记录到28个神经元分布于头、尾侧腹侧呼吸组、孤束核和中缝隐窝。呼吸周期和吸气驱动的时相由综合的传出膈神经活动来评估。经颈外动脉注射CO2饱和盐水刺激颈动脉化学感受器。压力感受器被降主动脉内的取栓术导管充气引起的血压升高所刺激。通过捏脚垫来刺激皮肤伤害性感受器。474个神经元被测试呼吸调制的放电频率和反应；403个神经元在所有3种刺激方式下被测试。化学感受器刺激和收缩，这两种倾向于增加呼吸动力的扰动，在52个神经元中引起了类似的反应；28个神经元的反应相反。化学感受器和压力感受器刺激在45个神经元中引起相似的初级反应；48个神经元的初级反应相反。38个神经元对压力感受器刺激和收缩的反应相似，26个神经元的反应相反。在同时记录到的神经元中，对不同方式的刺激有不同的放电率变化组合。结果表明，颈动脉化学感受器、压力感受器和皮肤伤害性感受器的信息在功能上汇聚在分布于延髓的呼吸调制神经元上。这些数据与脑干神经元在影响呼吸运动模式的多功能组中具有重叠成员关系的假设一致。
This study addresses the hypothesis that multiple afferent systems share elements of a distributed brain stem network that modulates the respiratory motor pattern. Data were collected from 18 decerebrate, bilaterally vagotomized, paralyzed, artificially ventilated cats. Up to 28 neurons distributed in the rostral and caudal ventral respiratory group, nucleus tractus solitarius, and raphe obscurus were recorded simultaneously with microelectrode arrays. Phases of the respiratory cycle and inspiratory drive were assessed from integrated efferent phrenic nerve activity. Carotid chemoreceptors were stimulated by injection of CO2-saturated saline solution via the external carotid artery. Baroreceptors were stimulated by increased blood pressure secondary to inflation of an embolectomy catheter in the descending aorta. Cutaneous nociceptors were stimulated by pinching a footpad. Four hundred seventy-four neurons were tested for respiratory modulated firing rates and responses; 403 neurons were tested with stimulation of all 3 modalities. Chemoreceptor stimulation and pinch, perturbations that tend to increase respiratory drive, caused similar responses in 52 neurons; 28 responded oppositely. Chemoreceptor and baroreceptor stimulation resulted in similar primary responses in 45 neurons; 48 responded oppositely. Similar responses to baroreceptor stimulation and pinch were recorded for 38 neurons; opposite effects were measured in 26 neurons. Among simultaneously recorded neurons, distinct combinations of firing rate changes were evoked in response to stimulation of the different modalities. The results show a functional convergence of information from carotid chemoreceptors, baroreceptors, and cutaneous nociceptors on respiratory-modulated neurons distributed in the medulla. The data are consistent with the hypothesis that brain stem neurons have overlapping memberships in multifunctional groups that influence the respiratory motor pattern.
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影响因子：
3.3
作者：
BISHOP, B
通讯作者：
BISHOP, B
急性低血容量后的低血压取决于尾部中线延髓
影响因子：
1.7
作者：
L. Henderson;K. Keay;R. Bandler
通讯作者：
R. Bandler
影响因子：
2.5
作者：
COHEN, MI
通讯作者：
COHEN, MI
猫髓质网状结构中线区神经元的反应特性和功能组织。
影响因子：
2.5
作者：
C. Yen;P. Blum
通讯作者：
P. Blum
呼吸神经元活动的一致性和信号强度。
影响因子：
2.5
作者：
Orem,J;Dick,T
通讯作者：
Dick,T