Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields.
Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields.
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DOI：
10.1016/j.cell.2017.05.024
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发表时间：
2017-06-01
期刊：
影响因子：
64.5
通讯作者：
Boyden ES
中科院分区：
文献类型：
--
作者：
Grossman N;Bono D;Dedic N;Kodandaramaiah SB;Rudenko A;Suk HJ;Cassara AM;Neufeld E;Kuster N;Tsai LH;Pascual-Leone A;Boyden ES
我们报告了一种非侵入性的策略，电刺激神经元的深度。通过以太高而不能募集神经放电的频率向大脑递送多个电场，但是其在神经放电的动态范围内的频率不同，我们可以电刺激整个区域的神经元，其中多个场之间的干扰导致在差频处调制的显著电场包络。我们通过建模和物理实验验证了这种时间干扰（TI）的概念，并验证了活体小鼠大脑中的神经元可以遵循电场包络。我们通过刺激活体小鼠海马中的神经元而不招募上覆皮层的神经元来证明TI刺激的效用。最后，我们表明，通过改变传递到一组固定电极的电流，我们可以在活体小鼠中立体地唤起不同的运动模式。无创性TI刺激可选择性地电刺激深部神经元通过多个电场之间的干扰刺激神经元可刺激小鼠海马神经元而不影响上覆皮层无创性脑深部电刺激方法可能是治疗神经精神疾病的新途径。
We report a noninvasive strategy for electrically stimulating neurons at depth. By delivering to the brain multiple electric fields at frequencies too high to recruit neural firing, but which differ by a frequency within the dynamic range of neural firing, we can electrically stimulate neurons throughout a region where interference between the multiple fields results in a prominent electric field envelope modulated at the difference frequency. We validated this temporal interference (TI) concept via modeling and physics experiments, and verified that neurons in the living mouse brain could follow the electric field envelope. We demonstrate the utility of TI stimulation by stimulating neurons in the hippocampus of living mice without recruiting neurons of the overlying cortex. Finally, we show that by altering the currents delivered to a set of immobile electrodes, we can steerably evoke different motor patterns in living mice. Noninvasive TI stimulation electrically stimulates neurons at depth selectively Neurons are stimulated by interference between multiple electric fields Neurons in mouse hippocampus can be stimulated without affecting the overlying cortex A noninvasive method for deep-brain stimulation may be a new approach for the treatment of neuropsychiatric diseases.
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DOI：
10.1111/ner.12100
发表时间：
2014-04
期刊：
Neuromodulation : journal of the International Neuromodulation Society
影响因子：
--
作者：
Kilgore KL;Bhadra N
通讯作者：
Bhadra N
影响因子：
3.7
作者：
Tennant, Kelly A.;Adkins, DeAnna L.;Jones, Theresa A.
通讯作者：
Jones, Theresa A.
影响因子：
25
作者：
Dobbin MM;Madabhushi R;Pan L;Chen Y;Kim D;Gao J;Ahanonu B;Pao PC;Qiu Y;Zhao Y;Tsai LH
通讯作者：
Tsai LH
DOI：
10.1016/s0169-328x(98)00040-0
发表时间：
1998-06-01
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
Ito, D;Imai, Y;Kohsaka, S
通讯作者：
Kohsaka, S
影响因子：
48
作者：
Kodandaramaiah, Suhasa B.;Franzesi, Giovanni Talei;Chow, Brian Y.;Boyden, Edward S.;Forest, Craig R.
通讯作者：
Forest, Craig R.