An evaluation of the preoperative hemoglobin level as a prognostic factor for oral squamous cell carcinoma.
An evaluation of the preoperative hemoglobin level as a prognostic factor for oral squamous cell carcinoma.
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DOI：
10.1186/1758-3284-3-35
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发表时间：
2011-08-15
期刊：
影响因子：
--
通讯作者：
Kruse AL
中科院分区：
文献类型：
--
作者：
Cordella C;Luebbers HT;Rivelli V;Grätz KW;Kruse AL
缺氧似乎是口腔鳞状细胞癌（SCC）的一个影响因素，并在这方面讨论了几个免疫组化标记。本研究的目的是评估术前血红蛋白水平作为口腔鳞状细胞癌的预后因素。回顾性研究了1999年至2008年期间接受口腔鳞癌治疗的287例患者的档案。将手术治疗前1 - 5天的血红蛋白水平与肿瘤（T）和淋巴结（N）状态、局部复发和淋巴结转移率进行比较。最短随访期为12个月。在总共287名口腔鳞状细胞癌患者中，血红蛋白（Hb）正常者占71.4（女性Hb≥12.0 g/dl;男性Hb≥13.0 g/dl），53轻度贫血组（女性Hb = 11.0- 11.9g/dl，男性Hb = 11.0- 12.9g/dl）29例（18.5%），重度贫血组（男女Hb<11.0g/dl）29例（10.1%）。贫血对淋巴结转移（p = 0.005）和局部复发（p = 0.001）的发生有显著意义。未发现与初始T状态的显著相关性（p = 0.183）。我们的数据表明，Hb低于11 g/dl有助于预后不良，并且是预后不良的指标。因此，治疗前血红蛋白校正可能会显着改善结果，但进一步的调查，包括输血/应用促红细胞生成素由于肿瘤贫血，独立于术中失血是必要的，以确定其在提高生存率的作用。
Hypoxia seems to be an influencing factor for oral squamous cell carcinomas (SCC), and several immunohistochemical markers have been discussed in this regard. The aim of the present study was to evaluate preoperative hemoglobin levels as a prognostic factor for oral SCC. The files of 287 patients who had been treated for oral SCC between 1999 and 2008 were studied retrospectively. Hemoglobin levels between 1 and 5 days prior to surgical treatment were compared to Tumor (T)- and Nodal (N)- status, local recurrence, and lymph node metastases rate. The minimum follow-up period was 12 months. From a total of 287 patients with oral SCC, 205 (71.4%) were in the normal hemoglobin (Hb) group (female Hb≥12.0 g/dl; male Hb≥13.0 g/dl), 53 (18.5%) in the mild anemia (female Hb = 11.0-11.9 g/dl; male Hb = 11.0-12.9 g/dl), and 29 (10.1%) in the severe anemia group (female & male Hb<11.0 g/dl). Anemia was significant for the development of lymph node metastasis (p = 0.005) as well as for local recurrence (p = 0.001). No significant correlation was found to the initial T status (p = 0.183). Our data suggests that an Hb of below 11 g/dl contributes to and is an indicator for a poor prognosis. Consequently, pre-treatment Hb corrections may significantly improve outcome, but further investigations, including blood transfusion/application of erythropoietin due to tumor anemia, independent of intraoperative blood-loss are necessary to ascertain their role in an improved survival.
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影响因子：
50.5
作者：
Boyle, P;Ferlay, J
通讯作者：
Ferlay, J
影响因子：
--
作者：
Moir, MS;Samy, RN;Terris, DJ
通讯作者：
Terris, DJ
影响因子：
3.4
作者：
VONDOERSTEN, P;CRUZ, RM;HILSINGER, RL
通讯作者：
HILSINGER, RL
影响因子：
2.6
作者：
EVANS, NTS;NAYLOR, PFD
通讯作者：
NAYLOR, PFD
影响因子：
45.3
作者：
DONOHUE, JH;WILLIAMS, S;MOERTEL, CG
通讯作者：
MOERTEL, CG