Discovering dominant tumor immune archetypes in a pan-cancer census.
Discovering dominant tumor immune archetypes in a pan-cancer census.
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在泛癌统计中发现主要的肿瘤免疫原型 。
DOI：
10.1016/j.cell.2021.12.004
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发表时间：
2022-01-06
期刊：
影响因子：
64.5
通讯作者：
Krummel MF
中科院分区：
文献类型：
--
作者：
Combes AJ;Samad B;Tsui J;Chew NW;Yan P;Reeder GC;Kushnoor D;Shen A;Davidson B;Barczak AJ;Adkisson M;Edwards A;Naser M;Barry KC;Courau T;Hammoudi T;Argüello RJ;Rao AA;Olshen AB;Immunoprofiler Consortium;Cai C;Zhan J;Davis KC;Kelley RK;Chapman JS;Atreya CE;Patel A;Daud AI;Ha P;Diaz AA;Kratz JR;Collisson EA;Fragiadakis GK;Erle DJ;Boissonnas A;Asthana S;Chan V;Krummel MF
癌症在起源组织、驱动突变和周围组织的其他特征方面显示出显著的异质性。很可能个体肿瘤参与免疫系统的共同模式-这里是“原型”-创建原型非破坏性肿瘤免疫微环境（TME）并调节肿瘤靶向。为了发现主要的免疫系统原型，UCSF免疫分析仪计划（IPI）使用标准化方案处理了12种癌症类型的364个个体肿瘤。从细胞亚区室获得的流式细胞术和转录组学数据的计算聚类揭示了癌症中免疫组成的主导模式。这些原型意义深远，因为它们还基于独特的免疫和肿瘤基因表达模式来区分肿瘤。他们还划分了肿瘤生物学的成熟分类。IPI资源为理解癌症免疫作为免疫组织的主要模式的集合提供了一个模板，并为学习如何调节这些模式以改善治疗提供了一条合理的途径。
Cancers display significant heterogeneity with respect to tissue of origin, driver mutations and other features of the surrounding tissue. It is likely that individual tumors engage common patterns of the immune system—here ‘Archetypes’—creating prototypical non-destructive tumor immune microenvironments (TME) and modulating tumor-targeting. To discover the dominant immune system archetypes the UCSF Immunoprofiler Initiative (IPI) processed 364 individual tumors across 12 cancer types using standardized protocols. Computational clustering of flow cytometry and transcriptomic data obtained from cell sub-compartments uncovered dominant patterns of immune composition across cancers. These archetypes were profound insofar as they also differentiated tumors based upon unique immune and tumor gene-expression patterns. They also partitioned well-established classifications of tumor biology. The IPI resource provides a template for understanding cancer immunity as a collection of dominant patterns of immune organization and provides a rational path forward to learn how to modulate these to improve therapy.
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通讯作者：
Krummel MF