Epigenomic disruption: the effects of early developmental exposures.
Epigenomic disruption: the effects of early developmental exposures.
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DOI：
10.1002/bdra.20685
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发表时间：
2010-10
影响因子：
--
通讯作者：
Jirtle, Randy L.
中科院分区：
文献类型：
--
作者：
Bernal, Autumn J.;Jirtle, Randy L.
关键词：
通过DNA甲基化，组蛋白修饰和小的调节RNA，表观基因组系统地控制发育过程中的基因表达-无论是在子宫内还是在整个生命中。表观基因组也是一个非常反动的系统;其不稳定的性质使其能够感知和应对环境扰动，以确保胎儿生长期间的生存。这种柔韧性可能导致异常的表观遗传修饰，持续到以后的生活，并诱发许多疾病状态。内分泌干扰化合物（EDCs）是普遍存在的化学物质，干扰生长和发育。几种内分泌干扰物也会干扰表观遗传编程。对双酚A（BPA）（一种用于塑料和树脂生产的EDC）的表观遗传毒性效应的研究进一步引起了人们对EDC对表观基因组影响的关注。使用Agglutinalviable yellow（Avy）小鼠模型，膳食BPA暴露显示Avy和CabpIAP亚稳表观等位基因低甲基化。这种低甲基化作用被膳食补充甲基供体或染料木黄酮抵消。这些结果与BPA和其他引起表观遗传效应的内分泌干扰物的报告一致。表观遗传毒性可能导致暴露人群中的许多发育、代谢和行为障碍。表观遗传变化的可遗传性也增加了表型跨代遗传的风险。因此，在评估这些化合物的安全性时，必须考虑表观遗传毒性。
Through DNA methylation, histone modifications, and small regulatory RNAs the epigenome systematically controls gene expression during development-- both in utero and throughout life. The epigenome is also a very reactionary system; its labile nature allows it to sense and respond to environmental perturbations to ensure survival during fetal growth. This pliability can lead to aberrant epigenetic modifications that persist into later life and induce numerous disease states. Endocrine disrupting compounds (EDCs) are ubiquitous chemicals that interfere with growth and development. Several EDCs also interfere with epigenetic programming. The investigation of the epigenotoxic effects of bisphenol A (BPA), an EDC used in the production of plastics and resins, has further raised concern for the impact of EDCs on the epigenome. Using the Agouti viable yellow (Avy) mouse model, dietary BPA exposure was shown to hypomethylate both the Avy and the CabpIAP metastable epialleles. This hypomethylating effect was counteracted with dietary supplementation of methyl donors or genistein. These results are consistent with reports of BPA and other EDCs causing epigenetic effects. Epigenotoxicity could lead to numerous developmental, metabolic, and behavioral disorders in exposed populations. The heritable nature of epigenetic changes also increases the risk for transgenerational inheritance of phenotypes. Thus, epigenotoxicity must be considered when assessing these compounds for safety.
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影响因子：
3.7
作者：
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DOI：
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发表时间：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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