Apparent nosocomial adaptation of Enterococcus faecalis predates the modern hospital era.
Apparent nosocomial adaptation of Enterococcus faecalis predates the modern hospital era.
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DOI：
10.1038/s41467-021-21749-5
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发表时间：
2021-03-09
影响因子：
16.6
通讯作者：
Corander J
中科院分区：
文献类型：
--
作者：
Pöntinen AK;Top J;Arredondo-Alonso S;Tonkin-Hill G;Freitas AR;Novais C;Gladstone RA;Pesonen M;Meneses R;Pesonen H;Lees JA;Jamrozy D;Bentley SD;Lanza VF;Torres C;Peixe L;Coque TM;Parkhill J;Schürch AC;Willems RJL;Corander J
粪肠球菌（Enterococcus faecalis）是一种广泛存在于动物和昆虫体内的病原菌，是一种典型的多面手微生物。在这里，我们研究E。粪肠球菌分离株的范围从1936年的前抗生素时代到2018年，涵盖了大量的宿主物种，包括野生鸟类、哺乳动物、健康人类和住院患者。我们使用短读和长读技术对细菌基因组进行测序，并确定了多种现存的医院相关谱系，最后的共同祖先可以追溯到世纪。我们发现一个群体通过同源重组紧密相连，尽管基因组大小很小，但代谢灵活性，以及稳定的大核心基因组。我们的研究结果表明，在医院相关的E。粪肠球菌谱系可能早于“现代医院”时代，提示在另一个小生境中的选择，并强调这种医院病原体的通才性质。粪肠球菌（Enterococcus faecalis）是动物、昆虫和人类的肠道微生物，也是医院获得性病原体。在这里，作者分析了E.从动物和人类中分离出的粪肠球菌，并发现多个医院相关谱系的最后共同祖先可以追溯到抗生素出现之前的时代。
Enterococcus faecalis is a commensal and nosocomial pathogen, which is also ubiquitous in animals and insects, representing a classical generalist microorganism. Here, we study E. faecalis isolates ranging from the pre-antibiotic era in 1936 up to 2018, covering a large set of host species including wild birds, mammals, healthy humans, and hospitalised patients. We sequence the bacterial genomes using short- and long-read techniques, and identify multiple extant hospital-associated lineages, with last common ancestors dating back as far as the 19th century. We find a population cohesively connected through homologous recombination, a metabolic flexibility despite a small genome size, and a stable large core genome. Our findings indicate that the apparent hospital adaptations found in hospital-associated E. faecalis lineages likely predate the “modern hospital” era, suggesting selection in another niche, and underlining the generalist nature of this nosocomial pathogen. Enterococcus faecalis is a commensal microorganism of animals, insects and humans, but also a nosocomial pathogen. Here, the authors analyse genomic sequences from E. faecalis isolates from animals and humans, and find that the last common ancestors of multiple hospital-associated lineages date to the pre-antibiotic era.
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核心基因组中最近的重组事件与粪肠球菌的自适应进化有关。
影响因子：
3.3
作者：
de Been M;van Schaik W;Cheng L;Corander J;Willems RJ
通讯作者：
Willems RJ
DOI：
10.1093/bioinformatics/btx610
发表时间：
2018-01-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Hadfield J;Croucher NJ;Goater RJ;Abudahab K;Aanensen DM;Harris SR
通讯作者：
Harris SR
影响因子：
14.9
作者：
Haft DH;DiCuccio M;Badretdin A;Brover V;Chetvernin V;O'Neill K;Li W;Chitsaz F;Derbyshire MK;Gonzales NR;Gwadz M;Lu F;Marchler GH;Song JS;Thanki N;Yamashita RA;Zheng C;Thibaud-Nissen F;Geer LY;Marchler-Bauer A;Pruitt KD
通讯作者：
Pruitt KD
影响因子：
3.9
作者：
Argimón S;Abudahab K;Goater RJE;Fedosejev A;Bhai J;Glasner C;Feil EJ;Holden MTG;Yeats CA;Grundmann H;Spratt BG;Aanensen DM
通讯作者：
Aanensen DM
影响因子：
30.8
作者：
Feasey, Nicholas A.;Hadfield, James;Keddy, Karen H.;Dallman, Timothy J.;Jacobs, Jan;Deng, Xiangyu;Wigley, Paul;Barquist, Lars Barquist;Langridge, Gemma C.;Feltwell, Theresa;Harris, Simon R.;Mather, Alison E.;Fookes, Maria;Aslett, Martin;Msefula, Chisomo;Kariuki, Samuel;Maclennan, Calman A.;Onsare, Robert S.;Weill, Francois-Xavier;Le Hello, Simon;Smith, Anthony M.;McClelland, Michael;Desai, Prerak;Parry, Christopher M.;Cheesbrough, John;French, Neil;Campos, Josefina;Chabalgoity, Jose A.;Betancor, Laura;Hopkins, Katie L.;Nair, Satheesh;Humphrey, Tom J.;Lunguya, Octavie;Cogan, Tristan A.;Tapia, Milagritos D.;Sow, Samba O.;Tennant, Sharon M.;Bornstein, Kristin;Levine, Myron M.;Lacharme-Lora, Lizeth;Everett, Dean B.;Kingsley, Robert A.;Parkhill, Julian;Heyderman, Robert S.;Dougan, Gordon;Gordon, Melita A.;Thomson, Nicholas R.
通讯作者：
Thomson, Nicholas R.