Neurocognitive correlates of white matter quality in adolescent substance users.
Neurocognitive correlates of white matter quality in adolescent substance users.
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DOI：
10.1016/j.bandc.2009.10.012
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发表时间：
2010-04
影响因子：
2.5
通讯作者：
Tapert, Susan F.
中科院分区：
文献类型：
--
作者：
Bava, Sunita;Jacobus, Joanna;Mahmood, Omar;Yang, Tony T.;Tapert, Susan F.
青春期的进行性髓鞘形成意味着对神经毒性物质的易感性增加，并导致持久的神经认知后果。这项研究考察了长期吸食大麻和酗酒(MJ+ALC)青少年脑白质微结构改变的认知表现。对36名MJ+ALC青少年(年龄16-19岁)和36名人口学上相似的对照组进行了扩散张量成像和神经认知测试。分析了分数各向异性(FA)和平均扩散率(MD)的群体差异区域与认知表现的关系。在用户中，较低的时间区域FA与较差的注意力、工作记忆和加速处理任务的表现有关。在使用者的FA高于对照组的区域中，枕区FA与工作记忆和复杂视觉运动排序呈正相关，而前区FA与言语记忆成绩呈负相关。研究结果表明，在使用MJ+ALC的青少年中，白质发育对认知的影响与不使用同龄人的不同。神经适应可能反映了对物质使用的加性和减性反应，这些反应因相互竞争的成熟过程而变得复杂。
Progressive myelination during adolescence implicates an increased vulnerability to neurotoxic substances and enduring neurocognitive consequences. This study examined the cognitive manifestations of altered white matter microstructure in chronic marijuana and alcohol-using (MJ+ALC) adolescents. Thirty-six MJ+ALC adolescents (ages 16-19) and 36 demographically similar controls were evaluated with diffusion tensor imaging and neurocognitive tests. Regions of group difference in fractional anisotropy (FA) and mean diffusivity (MD) were analyzed in relation to cognitive performance. In users, lower FA in temporal areas related to poorer performance on attention, working memory, and speeded processing tasks. Among regions where users had higher FA than controls, occipital FA was positively associated with working memory and complex visuomotor sequencing, whereas FA in anterior regions was negatively associated with verbal memory performance. Findings suggest differential influences of white matter development on cognition in MJ+ALC using adolescents than in non-using peers. Neuroadaptation may reflect additive and subtractive responses to substance use that are complicated by competing maturational processes.
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影响因子：
3.6
作者：
Fant, RV;Heishman, SJ;Pickworth, WB
通讯作者：
Pickworth, WB
DOI：
10.1111/j.1530-0277.2007.00603.x
发表时间：
2008-03-01
影响因子：
3.2
作者：
De Bellis, Michael D.;Van Voorhees, Elizabeth;MacFall, James
通讯作者：
MacFall, James
DOI：
10.15288/jsa.1998.59.427
发表时间：
1998-07-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
Brown, SA;Myers, MG;Vik, PW
通讯作者：
Vik, PW
影响因子：
4.8
作者：
Ashtari M;Cervellione K;Cottone J;Ardekani BA;Sevy S;Kumra S
通讯作者：
Kumra S
DOI：
10.1097/01.alc.0000179368.87886.76
发表时间：
2005-09-01
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
De Bellis, Michael D;Narasimhan, Anandhi;Clark, Duncan B
通讯作者：
Clark, Duncan B