Identifying molecular mediators of environmentally enhanced neurogenesis.
Identifying molecular mediators of environmentally enhanced neurogenesis.
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DOI：
10.1007/s00441-017-2718-5
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发表时间：
2018-01
影响因子：
3.6
通讯作者：
Zhao X
中科院分区：
文献类型：
--
作者：
Eisinger BE;Zhao X
成年海马区神经发生贯穿一生，并支持健康的大脑功能。新神经元的产生随着年龄的增长而减少，成人神经发生的缺陷与神经发育和退行性疾病有关。神经发生的速率对一个人的环境条件和经历是动态敏感的，某些刺激被认为可以在啮齿动物模型中强有力地促进神经发生，包括自愿运动、丰富的环境和电惊厥。在这些模型中，有关生物体环境和生理状态的信息通过一系列组织和细胞接口传递到海马区内的神经源性细胞类型，最终引发神经干细胞和新生神经元的神经源性反应。因此，了解新的基因和蛋白质如何在这种电路水平的特定细胞类型中发挥作用，具有科学和治疗价值。一些经过充分研究的神经营养因子与环境增强的神经发生有关，这篇综述将着重介绍最近发现的响应环境提示的神经发生的新的分子介质。此外，还将总结大规模基因表达和功能评估技术的进步对过去、现在和未来阐明环境增强型神经发生的细胞类型特异性分子介质的贡献。
Adult hippocampal neurogenesis occurs throughout life and supports healthy brain functions. The production of new neurons decreases with age and deficiencies in adult neurogenesis are associated with neurodevelopmental and degenerative disease. The rate of neurogenesis is dynamically sensitive to one’s environmental conditions and experiences, and certain stimuli are known to robustly enhance neurogenesis in rodent models, including voluntary exercise, enriched environment, and electroconvulsive shock. In these models, information about an organism’s environment and physiological state are relayed to neurogenic cell types within the hippocampus through a series of tissue and cellular interfaces, ultimately eliciting a neurogenic response from neural stem cells and newborn neurons. Therefore, understanding how novel genes and proteins act in specific cell types within this circuit-level context is of scientific and therapeutic value. Several well-studied neurotrophic factors have been implicated in environmentally-enhanced neurogenesis, and this review will serve to highlight recently-discovered, novel molecular mediators of neurogenesis in response to environmental cues. Furthermore, the contribution of advancing large-scale gene expression and function assessment technology to past, present, and future efforts to elucidate cell type-specific molecular mediators of environmentally-enhanced neurogenesis will be summarized.
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影响因子：
3.5
作者：
Darcy, Michael J.;Trouche, Stephanie;Jin, Shan-Xue;Feig, Larry A.
通讯作者：
Feig, Larry A.
DOI：
10.3233/bpl-150020
发表时间：
2015-10-09
期刊：
Brain plasticity (Amsterdam, Netherlands)
影响因子：
--
作者：
Bolijn S;Lucassen PJ
通讯作者：
Lucassen PJ
DOI：
10.1016/j.bbi.2015.11.001
发表时间：
2016-07
期刊：
Brain, behavior, and immunity
影响因子：
--
作者：
De Lucia C;Rinchon A;Olmos-Alonso A;Riecken K;Fehse B;Boche D;Perry VH;Gomez-Nicola D
通讯作者：
Gomez-Nicola D
影响因子：
8.2
作者：
Balu, Darrick T.;Lucki, Irwin
通讯作者：
Lucki, Irwin
影响因子：
3.5
作者：
Dieni CV;Chancey JH;Overstreet-Wadiche LS
通讯作者：
Overstreet-Wadiche LS