Converging on a core cognitive deficit: the impact of various neurodevelopmental insults on cognitive control.
Converging on a core cognitive deficit: the impact of various neurodevelopmental insults on cognitive control.
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DOI：
10.3389/fnins.2014.00153
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发表时间：
2014
影响因子：
4.3
通讯作者：
Fenton AA
中科院分区：
文献类型：
--
作者：
O'Reilly KC;Kao HY;Lee H;Fenton AA
尽管付出了巨大的努力和巨大的需求，但精神分裂症等主要神经精神疾病的治疗选择是有限的，而且在改善最令人衰弱的认知症状方面基本无效，这些症状是精神疾病的核心。这些症状包括认知控制缺陷，无法选择性地使用当前相关的信息，忽略当前不相关的信息。当代试图加速进步的努力部分建立在将神经精神疾病重新概念化为神经发育障碍的努力之上。这种神经发育框架一方面强调异常的神经回路，另一方面，它表明有治疗的机会，利用兴奋性神经元修剪，抑制性神经元增殖，髓鞘形成的阐述，以及其他电路的完善，延伸到青春期和成年早期的发展过程。我们精心设计了一个临床前研究计划，旨在研究可能与精神疾病有关的认知障碍。通过与各种神经发育啮齿动物模型，我们努力确定一个共同的病理生理学，认知控制失败的基础，以及一个共同的策略，以提高认知在面对神经回路异常。在这里，我们回顾了我们的工作，以表征认知控制缺陷的大鼠与新生儿腹侧海马病变和大鼠暴露于甲基偶氮甲醇乙酸酯（MAM）在子宫内。我们回顾了我们的研究结果，因为它们涉及早期发育过程，包括神经发生，以及认知经验的力量，以完善成熟和成熟的大脑认知回路中的神经回路功能。
Despite substantial effort and immense need, the treatment options for major neuropsychiatric illnesses like schizophrenia are limited and largely ineffective at improving the most debilitating cognitive symptoms that are central to mental illness. These symptoms include cognitive control deficits, the inability to selectively use information that is currently relevant and ignore what is currently irrelevant. Contemporary attempts to accelerate progress are in part founded on an effort to reconceptualize neuropsychiatric illness as a disorder of neural development. This neuro-developmental framework emphasizes abnormal neural circuits on the one hand, and on the other, it suggests there are therapeutic opportunities to exploit the developmental processes of excitatory neuron pruning, inhibitory neuron proliferation, elaboration of myelination, and other circuit refinements that extend through adolescence and into early adulthood. We have crafted a preclinical research program aimed at cognition failures that may be relevant to mental illness. By working with a variety of neurodevelopmental rodent models, we strive to identify a common pathophysiology that underlies cognitive control failure as well as a common strategy for improving cognition in the face of neural circuit abnormalities. Here we review our work to characterize cognitive control deficits in rats with a neonatal ventral hippocampus lesion and rats that were exposed to Methylazoxymethanol acetate (MAM) in utero. We review our findings as they pertain to early developmental processes, including neurogenesis, as well as the power of cognitive experience to refine neural circuit function within the mature and maturing brain's cognitive circuitry.
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影响因子：
2.5
作者：
Cimadevilla, JM;Fenton, AA;Bures, J
通讯作者：
Bures, J
影响因子：
1.7
作者：
Barlow, H B
通讯作者：
Barlow, H B
DOI：
10.1073/pnas.95.6.3182
发表时间：
1998-03-17
影响因子：
11.1
作者：
Fenton, AA;Muller, RU
通讯作者：
Muller, RU
影响因子：
56.9
作者：
Clem, Roger L.;Celikel, Tansu;Barth, Alison L.
通讯作者：
Barth, Alison L.
影响因子：
2.7
作者：
Beninger, Richard J.;Tuerke, Katharine J.;Jhamandas, Khem
通讯作者：
Jhamandas, Khem