Epistasis--the essential role of gene interactions in the structure and evolution of genetic systems.
Epistasis--the essential role of gene interactions in the structure and evolution of genetic systems.
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DOI:
10.1038/nrg2452
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发表时间:
2008-11
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--
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Epistasis, or interactions between genes, has long been recognized to be fundamentally important to understanding both the structure and function of genetic pathways and the evolutionary dynamics of complex genetic systems. With the advent of high throughput functional genomics and the emergence of systems approaches to biology, as well as a newfound ability to pursue the genetic basis of evolution down to specific molecular changes, there is a renewed appreciation both for the importance of studying gene interactions and for addressing these questions in a unified, quantitative manner.
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