Epistasis--the essential role of gene interactions in the structure and evolution of genetic systems.

Epistasis--the essential role of gene interactions in the structure and evolution of genetic systems.
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DOI:
10.1038/nrg2452
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发表时间:
2008-11
期刊:
Nature reviews. Genetics
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其他
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长期以来,人们一直认为上位性或基因之间的相互作用对于理解遗传途径的结构和功能以及复杂遗传系统的进化动力学至关重要。随着高通量功能基因组学的出现和生物学系统方法的出现,以及新发现的追寻进化遗传基础直至特定分子变化的能力,人们对研究基因相互作用和以统一、定量的方式解决这些问题的重要性有了新的认识。
Epistasis, or interactions between genes, has long been recognized to be fundamentally important to understanding both the structure and function of genetic pathways and the evolutionary dynamics of complex genetic systems. With the advent of high throughput functional genomics and the emergence of systems approaches to biology, as well as a newfound ability to pursue the genetic basis of evolution down to specific molecular changes, there is a renewed appreciation both for the importance of studying gene interactions and for addressing these questions in a unified, quantitative manner.
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