Effects of age, task performance, and structural brain development on face processing.
Effects of age, task performance, and structural brain development on face processing.
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DOI：
10.1093/cercor/bhs150
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发表时间：
2013-07
期刊：
影响因子：
--
通讯作者：
Blakemore SJ
中科院分区：
文献类型：
--
作者：
Cohen Kadosh K;Johnson MH;Dick F;Cohen Kadosh R;Blakemore SJ
在这项结构和功能MRI发展研究相结合的研究中，我们对48名7-37岁的参与者进行了3项简单的面部处理任务(身份、表情和凝视任务)的测试，这些任务的设计在整个年龄范围内产生了非常相似的表现水平。然后，相同的参与者执行了3个更难的扫描仪外任务，这些任务提供了对性能变化的深入测量。在我们的分析中，我们采用了一种新颖的、系统的方法，使我们能够区分三项任务中大胆反应中与年龄和表现相关的变化，并将这些影响与伴随的大脑结构变化进行比较。对所有面孔特征的处理激活了整个年龄范围的核心面孔网络，以及额外的和部分可分离的区域。研究发现，后脑区域的小任务特异性激活随着年龄的增加而增加，与更广泛的激活不同，后者随着个体任务表现的不同而不同(但不随年龄)。我们的结果表明，面孔加工过程中的活动随着年龄的增长而变化，当控制与任务表现差异相关的变化时，仍然可以观察到这些影响。此外，我们发现，白质和灰质体积的变化与激活随年龄和在扫描仪外任务中的表现的变化有关。
In this combined structural and functional MRI developmental study, we tested 48 participants aged 7–37 years on 3 simple face-processing tasks (identity, expression, and gaze task), which were designed to yield very similar performance levels across the entire age range. The same participants then carried out 3 more difficult out-of-scanner tasks, which provided in-depth measures of changes in performance. For our analysis we adopted a novel, systematic approach that allowed us to differentiate age- from performance-related changes in the BOLD response in the 3 tasks, and compared these effects to concomitant changes in brain structure. The processing of all face aspects activated the core face-network across the age range, as well as additional and partially separable regions. Small task-specific activations in posterior regions were found to increase with age and were distinct from more widespread activations that varied as a function of individual task performance (but not of age). Our results demonstrate that activity during face-processing changes with age, and these effects are still observed when controlling for changes associated with differences in task performance. Moreover, we found that changes in white and gray matter volume were associated with changes in activation with age and performance in the out-of-scanner tasks.
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DOI：
10.1093/cercor/bhq215
发表时间：
2011-06
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Cohen Kadosh K;Cohen Kadosh R;Dick F;Johnson MH
通讯作者：
Johnson MH
影响因子：
3.7
作者：
Fairhall, Scott L.;Ishai, Alumit
通讯作者：
Ishai, Alumit
影响因子：
1.7
作者：
Gathers, AD;Bhatt, R;Joseph, JE
通讯作者：
Joseph, JE
影响因子：
2.6
作者：
HUTTENLOCHER, PR
通讯作者：
HUTTENLOCHER, PR
影响因子：
3.7
作者：
Brown, TT;Lugar, HM;Schlaggar, BL
通讯作者：
Schlaggar, BL