The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI.
The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI.
复制标题
肥胖相关基因座在全基因组关联研究中鉴定出的作用在小儿BMI的测定中。
DOI：
10.1038/oby.2009.159
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发表时间：
2009-12
期刊：
影响因子：
6.9
通讯作者：
Grant, Struan F. A.
中科院分区：
文献类型：
--
作者：
Zhao, Jianhua;Bradfield, Jonathan P.;Li, Mingyao;Wang, Kai;Zhang, Haitao;Kim, Cecilia E.;Annaiah, Kiran;Glessner, Joseph T.;Thomas, Kelly;Garris, Maria;Frackelton, Edward C.;Otieno, F. George;Shaner, Julie L.;Smith, Ryan M.;Chiavacci, Rosetta M.;Berkowitz, Robert I.;Hakonarson, Hakon;Grant, Struan F. A.
在过去的十年中，美国儿童和成人肥胖症的患病率急剧增加。除了环境因素外，遗传因素在肥胖的发病机制中也起着重要作用。通过全基因组关联研究，已经确定了成人BMI的一些遗传决定因素。在这项研究中，我们检测了25个单核苷酸多态性（SNP），对应于先前报道的13个基因组位点，在6,078名儿童中测量BMI。这些SNPs中有15个与BMI产生了至少名义上显著的关联，代表9个不同的基因座，包括INSIG 2、FTO、MC 4 R、TMEM 18、GNPDA 2、NEGR 1、BDNF、KCTD 15和1 q25。其他基因座没有发现相关证据，即MTCH 2，SH 2B 1，12 q13和3q 27。对于15个相关变异，基因型评分解释了BMI z评分总变异的1.12%。我们的结论是，在13个已报告与成人BMI相关的基因座中，至少有9个也有助于确定儿童时期的BMI，这一点在我们的儿科队列中得到了证实。
The prevalence of obesity in children and adults in the United States has increased dramatically over the past decade. Besides environmental factors, genetic factors are known to play an important role in the pathogenesis of obesity. A number of genetic determinants of adult BMI have already been established through genome wide association studies. In this study, we examined 25 single nucleotide polymorphisms (SNPs) corresponding to thirteen previously reported genomic loci in 6,078 children with measures of BMI. Fifteen of these SNPs yielded at least nominally significant association to BMI, representing nine different loci including INSIG2, FTO, MC4R, TMEM18, GNPDA2, NEGR1, BDNF, KCTD15 and 1q25. Other loci revealed no evidence for association, namely at MTCH2, SH2B1, 12q13 and 3q27. For the 15 associated variants, the genotype score explained 1.12% of the total variation for BMI z-score. We conclude that among thirteen loci that have been reported to associate with adult BMI, at least nine also contribute to the determination of BMI in childhood as demonstrated by their associations in our pediatric cohort.
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影响因子：
3.2
作者：
Gunstad, J;Chofield, P;Gordon, E
通讯作者：
Gordon, E
影响因子：
56.9
作者：
Frayling, Timothy M.;Timpson, Nicholas J.;McCarthy, Mark I.
通讯作者：
McCarthy, Mark I.
影响因子：
30.8
作者：
Loos, Ruth J. F.;Lindgren, Cecilia M.;Li, Shengxu;Wheeler, Eleanor;Zhao, Jing Hua;Prokopenko, Inga;Inouye, Michael;Freathy, Rachel M.;Attwood, Antony P.;Beckmann, Jacques S.;Berndt, Sonja I.;Bergmann, Sven;Bennett, Amanda J.;Bingham, Sheila A.;Bochud, Murielle;Brown, Morris;Cauchi, Stephane;Connell, John M.;Cooper, Cyrus;Smith, George Davey;Day, Ian;Dina, Christian;De, Subhajyoti;Dermitzakis, Emmanouil T.;Doney, Alex S. F.;Elliott, Katherine S.;Elliott, Paul;Evans, David M.;Farooqi, I. Sadaf;Froguel, Philippe;Ghori, Jilur;Groves, Christopher J.;Gwilliam, Rhian;Hadley, David;Hall, Alistair S.;Hattersley, Andrew T.;Hebebrand, Johannes;Heid, Iris M.;Herrera, Blanca;Hinney, Anke;Hunt, Sarah E.;Jarvelin, Marjo-Riitta;Johnson, Toby;Jolley, Jennifer D. M.;Karpe, Fredrik;Keniry, Andrew;Khaw, Kay-Tee;Luben, Robert N.;Mangino, Massimo;Marchini, Jonathan;McArdle, Wendy L.;McGinnis, Ralph;Meyre, David;Munroe, Patricia B.;Morris, Andrew D.;Ness, Andrew R.;Neville, Matthew J.;Nica, Alexandra C.;Ong, Ken K.;O'Rahilly, Stephen;Owen, Katharine R.;Palmer, Colin N. A.;Papadakis, Konstantinos;Potter, Simon;Pouta, Anneli;Qi, Lu;Randall, Joshua C.;Rayner, Nigel W.;Ring, Susan M.;Sandhu, Manjinder S.;Scherag, Andre;Sims, Matthew A.;Song, Kijoung;Soranzo, Nicole;Speliotes, Elizabeth K.;Syddall, Holly E.;Teichmann, Sarah A.;Timpson, Nicholas J.;Tobias, Jonathan H.;Uda, Manuela;Vogel, Carla I. Ganz;Wallace, Chris;Waterworth, Dawn M.;Weedon, Michael N.;Willer, Cristen J.;Wraight, Vicki L.;Yuan, Xin;Zeggini, Eleftheria;Hirschhorn, Joel N.;Strachan, David P.;Ouwehand, Willem H.;Caulfield, Mark J.;Samani, Nilesh J.;Frayling, Timothy M.;Vollenweider, Peter;Waeber, Gerard;Mooser, Vincent;Deloukas, Panos;McCarthy, Mark I.;Wareham, Nicholas J.;Barroso, Ines
通讯作者：
Barroso, Ines
影响因子：
64.8
作者：
Hakonarson, Hakon;Grant, Struan F. A.;Polychronakos, Constantin
通讯作者：
Polychronakos, Constantin
影响因子：
3.5
作者：
Hotta, Kikuko;Nakamura, Michihiro;Nakata, Yoshio;Matsuo, Tomoaki;Kamohara, Seika;Kotani, Kazuaki;Komatsu, Ryoya;Itoh, Naoto;Mineo, Ikuo;Wada, Jun;Masuzaki, Hiroaki;Yoneda, Masato;Nakajima, Atsushi;Miyazaki, Shigeru;Tokunaga, Katsuto;Kawamoto, Manabu;Funahashi, Tohru;Hamaguchi, Kazuyuki;Yamada, Kentaro;Hanafusa, Toshiaki;Oikawa, Shinichi;Yoshimatsu, Hironobu;Nakao, Kazuwa;Sakata, Toshiie;Matsuzawa, Yuji;Tanaka, Kiyoji;Kamatani, Naoyuki;Nakamura, Yusuke
通讯作者：
Nakamura, Yusuke