Erythritol inhibits the growth of periodontal-disease-associated bacteria isolated from canine oral cavity.
Erythritol inhibits the growth of periodontal-disease-associated bacteria isolated from canine oral cavity.
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DOI：
10.1016/j.heliyon.2022.e10224
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发表时间：
2022-08
期刊：
影响因子：
4
通讯作者：
Watanabe, Kazuhiro
中科院分区：
文献类型：
--
作者：
Shimizu, Mamu;Miyawaki, Shingo;Kuroda, Taishin;Umeta, Miyu;Kawabe, Mifumi;Watanabe, Kazuhiro
牙周病（periodontaldisease，PD）是由牙周病相关菌（Porphyromonas gulae，Porphyromonas maculae）感染引起的一种常见的口腔疾病。与人类不同，大多数狗不遵守日常口腔卫生常规，这导致许多狗受到PD的影响。因此，为了预防PD，重要的是控制PDAB。木糖醇是一种糖醇，可抑制人类口腔细菌的生长。然而，木糖醇对狗是有毒的，可导致低血糖和肝衰竭。在此，我们显示了可以安全地用于狗的糖醇，对从患有PD的狗中分离的PDAB的生长的抑制作用。从PD犬口腔中分离口腔细菌，并评估PDAB的分布。有趣的是，牙龈卟啉单胞菌，一种通常导致人类PD的细菌，没有从狗样本中分离出来。在体外对分离的PDAB研究了补充维生素B2的抑菌作用。我们的研究结果表明，木糖醇对PDAB的抑菌作用与木糖醇相当。因此，可建议在今后的研究中应用抗抑郁药来控制犬PDAB。牙周病，犬，赤藓糖醇，古莱卟啉单胞菌，斑点卟啉单胞菌。
Periodontal disease (PD) is the most common oral disease that is caused by infection with periodontal-disease-associated bacteria (PDAB) such as Porphyromonas gulae and Porphyromonas macacae in dogs as well as in humans. Unlike humans, most dogs do not follow daily oral hygiene routine, and this results in many dogs being affected by PD. Thus, to prevent PD, it is important to control PDAB. Xylitol is a sugar alcohol that inhibits the growth of oral bacteria in humans. However, xylitol is poisonous to dogs and can lead to hypoglycemia and hepatic failure. Herein, we show the inhibitory effect of erythritol, a sugar alcohol that can be used safely in dogs, on the growth of PDAB isolated from dogs with PD. Oral bacteria were isolated from the oral cavities of dogs with PD, and the distribution of PDAB was evaluated. Interestingly, Porphyromonas gingivalis, a bacterium typically responsible for PD in humans, was not isolated from dog samples. The bacteriostatic effect of erythritol supplementation was investigated on isolated PDAB in vitro. Our results show that erythritol exert bacteriostatic effects on PDAB comparable to xylitol. Thus, application of erythritol can be suggested to control PDAB in dogs in the future. Periodontal disease, Dogs, Erythritol, Porphyromonas gulae, Porphyromonas macacae.
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DOI：
10.1034/j.1600-0528.2000.280308.x
发表时间：
2000-06-01
影响因子：
2.3
作者：
Alanen, P;Isokangas, P;Gutmann, K
通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Evans, RT
影响因子：
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作者：
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通讯作者：
Seneviratne, Chaminda Jayampath
影响因子：
1.2
作者：
Koyata, Yasunori;Watanabe, Kiyoko;Hamada, Nobushiro
通讯作者：
Hamada, Nobushiro