Antimicrobial Peptides from Amphibian Innate Immune System as Potent Antidiabetic Agents: A Literature Review and Bioinformatics Analysis.
Antimicrobial Peptides from Amphibian Innate Immune System as Potent Antidiabetic Agents: A Literature Review and Bioinformatics Analysis.
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DOI：
10.1155/2021/2894722
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发表时间：
2021
影响因子：
4.3
通讯作者：
Hamidieh AA
中科院分区：
文献类型：
--
作者：
Soltaninejad H;Zare-Zardini H;Ordooei M;Ghelmani Y;Ghadiri-Anari A;Mojahedi S;Hamidieh AA
抗菌肽作为天然免疫系统的重要成员，除具有抗菌活性外，还具有多种生物学活性。有一些AMP具有抗糖尿病活性，特别是从两栖动物中分离的AMP。这些肽可以通过基于肽类型的不同机制诱导胰岛素释放。在这项综述研究中，我们收集了所有已报道的具有抗糖尿病活性的AMP。我们还分析了这些肽的序列和结构，以评估序列和结构对其抗糖尿病活性的影响。在此基础上，最大的具有抗糖尿病活性的肽家族是含9个抗糖尿病肽的时间肽。青蛙是最丰富的抗糖尿病肽的来源。生物信息学分析表明，增加肽的净正电荷和降低肽的疏水性可以提高肽的促胰岛素作用。具有较高正净电荷和博曼指数的肽表现出较高的活性。本文综述了具有抗糖尿病活性的抗菌肽，特别是两栖类抗菌肽，有望成为治疗2型糖尿病的新型药物。因此，两栖动物是潜在的活性肽来源，值得进一步评价为新的胰岛素促分泌剂。然而，必须考虑增加稳定性和积极活性以及减少负面副作用的策略。
Antimicrobial peptides, as an important member of the innate immune system, have various biological activities in addition to antimicrobial activity. There are some AMPs with antidiabetic activity, especially those isolated from amphibians. These peptides can induce insulin release via different mechanisms based on peptide type. In this review study, we collected all reported AMPs with antidiabetic activity. We also analyze the sequence and structure of these peptides for evaluation of sequence and structure effect on their antidiabetic activity. Based on this review, the biggest peptide family with antidiabetic activity is temporins with nine antidiabetic peptides. Frogs are the most abundant source of antidiabetic peptides. Bioinformatics analysis showed that an increase of positive net charge and a decrease of hydrophobicity can improve the insulinotropic effect of peptides. Peptides with higher positive net charge and Boman index showed higher activity. Based on this review article, AMPs with antidiabetic activity, especially those isolated from amphibians, can be used as novel antidiabetic drug for type 2 diabetes disease. So, amphibians are potential sources for active peptides which merit further evaluation as novel insulin secretagogues. However, strategy for the increase of stability and positive activity as well as the decrease of negative side effects must be considered.
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影响因子：
--
作者：
Conlon, J. Michael;Power, Gavin J.;Vaudry, Hubert
通讯作者：
Vaudry, Hubert
影响因子：
4
作者：
Marenah, L;Flatt, PR;Abdel-Wahab, YHA
通讯作者：
Abdel-Wahab, YHA
影响因子：
4.8
作者：
Andersen, Jan Terje;Dalhus, Bjorn;Cameron, Jason
通讯作者：
Cameron, Jason
影响因子：
3.7
作者：
Marenah, L;Flatt, PR;Abdel-Wahab, YHA
通讯作者：
Abdel-Wahab, YHA
影响因子：
4.7
作者：
Mo GX;Bai XW;Li ZJ;Yan XW;He XQ;Rong MQ
通讯作者：
Rong MQ