Role of Sleep Restriction in Daily Rhythms of Expression of Hypothalamic Core Clock Genes in Mice.
Role of Sleep Restriction in Daily Rhythms of Expression of Hypothalamic Core Clock Genes in Mice.
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睡眠限制对小鼠下丘脑核心时钟基因表达日节律的影响
DOI：
10.3390/cimb44020042
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发表时间：
2022-01-25
影响因子：
3.1
通讯作者：
Chen Y
中科院分区：
文献类型：
--
作者：
Li W;Wang Z;Cao J;Dong Y;Chen Y
睡眠时间不足是现代人的一大威胁，它会导致慢性疾病和精神疾病。昼夜节律过程控制睡眠，但人们对睡眠如何影响昼夜节律系统知之甚少。因此，我们在小鼠中进行了28天的睡眠限制（SR）治疗。睡眠限制扰乱了生物钟基因的昼夜节律。Cry 1和Per 1/2/3基因的昼夜节律消失。仍具有昼夜节律的生物钟基因（Bmal 1、Clock、Rev-erbα和Rorβ）的顶相提前，而负时钟基因Cry 2的顶相延迟。时钟基因上游信号ERK和EIFs也存在昼夜节律紊乱。伴随着中央振荡器的变化，血浆输出信号（褪黑激素、皮质酮、IL-6和TNF-α）具有提前的峰值相位。在褪黑素分泌减少的同时，皮质酮、IL-6和TNF-α分泌增加。我们的研究结果表明，慢性睡眠缺失可以通过ERK和EIF扰乱中枢生物钟的昼夜节律，并影响核心生物钟下游的输出信号。
Lack of sleep time is a menace to modern people, and it leads to chronic diseases and mental illnesses. Circadian processes control sleep, but little is known about how sleep affects the circadian system. Therefore, we performed a 28-day sleep restriction (SR) treatment in mice. Sleep restriction disrupted the clock genes’ circadian rhythm. The circadian rhythms of the Cry1 and Per1/2/3 genes disappeared. The acrophase of the clock genes (Bmal1, Clock, Rev-erbα, and Rorβ) that still had a circadian rhythm was advanced, while the acrophase of negative clock gene Cry2 was delayed. Clock genes’ upstream signals ERK and EIFs also had circadian rhythm disorders. Accompanied by changes in the central oscillator, the plasma output signal (melatonin, corticosterone, IL-6, and TNF-α) had an advanced acrophase. While the melatonin mesor was decreased, the corticosterone, IL-6, and TNF-α mesor was increased. Our results indicated that chronic sleep loss could disrupt the circadian rhythm of the central clock through ERK and EIFs and affect the output signal downstream of the core biological clock.
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影响因子：
3.4
作者：
Comasco E;Nordquist N;Göktürk C;Aslund C;Hallman J;Oreland L;Nilsson KW
通讯作者：
Nilsson KW
影响因子：
25
作者：
Cao, Ruifeng;Gkogkas, Christos G.;de Zavalia, Nuria;Blum, Ian D.;Yanagiya, Akiko;Tsukumo, Yoshinori;Xu, Haiyan;Lee, Choogon;Storch, Kai-Florian;Liu, Andrew C.;Amir, Shimon;Sonenberg, Nahum
通讯作者：
Sonenberg, Nahum
影响因子：
3.4
作者：
Antle, Michael C.;Tse, Floria;Hagel, Kimberly
通讯作者：
Hagel, Kimberly
影响因子：
3.5
作者：
Hendricks, JC;Lu, SM;Sehgal, A
通讯作者：
Sehgal, A
影响因子：
16
作者：
Harding, HP;Novoa, I;Ron, D
通讯作者：
Ron, D