Impact of the indigenous flora in animal models of shock and sepsis.
Impact of the indigenous flora in animal models of shock and sepsis.
复制标题
本土菌群对休克和败血症动物模型的影响。
DOI：
10.1097/01.shk.0000145935.24344.2d
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Erlandsen,StanleyL
中科院分区：
文献类型：
--
作者：
Wells,CarolL;Hess,DonavonJ;Erlandsen,StanleyL
败血症目前是美国第十大死亡原因，休克和创伤患者是与败血症相关的许多发病率和死亡率的来源。有大量证据表明，在休克和败血症的动物模型中，本地菌群的组成在调节结果变量方面起着重要作用。缺乏本地植物群的无菌动物不像传统饲养的动物那样容易受到冲击。而且，在传统饲养的动物中，肠道菌群的组成也可以调节休克和败血症的结果。例如，某些细菌种类/菌株比其他细菌更容易从肠道传播，抗生素诱导的菌群改变可以调节全身传播的发生率，肠道细菌的一定阈值数量有助于肠外传播。肠道菌群的组成也可以影响肠通透性、炎症介质的产生和肠外部位免疫细胞的反应。而且，有证据表明，先前通过口服或全身途径暴露于内毒素会影响肠外内毒素（一种广泛使用的内毒素休克模型）攻击动物的结果。实验动物肠道菌群的一般组成可以相对容易地表征。这些知识可以帮助数据解释，或者帮助解释不可重复的或预期的结果，或者验证观察到的差异可能与所研究的因变量有关，而不是与本地植物群的组成有关。
Septicemia is currently the 10th leading cause of death in the United States, and shock and trauma patients are the source of much of the morbidity and mortality associated with septicemia. There is substantial evidence that the composition of the indigenous flora plays an important role in modulating outcome variables in animal models of shock and sepsis. Germ-free animals that lack an indigenous flora are not as susceptible to shock as their conventionally reared counterparts. And, in conventionally reared animals, the composition of the intestinal flora can also modulate outcome in shock and sepsis. For example, certain bacterial species/strains disseminate from the intestinal tract more easily than others, antibiotic-induced alterations of the flora can modulate the incidence of systemic spread, and a certain threshold number of intestinal bacteria facilitates extraintestinal dissemination. The composition of the intestinal flora can also affect intestinal permeability, the production of inflammatory mediators, and the responses of immune cells in extraintestinal sites. And, there is evidence that prior exposure to endotoxin, via either the oral or systemic route, can influence outcome in animals challenged with parenteral endotoxin, a widely used model of endotoxin shock. The general composition of intestinal flora of experimental animals can be characterized with relative ease. This knowledge can aid data interpretation, either to help explain irreproducible or expected results or to verify that observed differences are likely related to the dependent variable studied rather than the composition of the indigenous flora.
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作者：
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DOI：
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发表时间：
2002
期刊：
American journal of physiology. Regulatory, integrative and comparative physiology
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作者：
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影响因子：
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作者：
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