Redox chemistry and chemical biology of H2S, hydropersulfides, and derived species: implications of their possible biological activity and utility.
Redox chemistry and chemical biology of H2S, hydropersulfides, and derived species: implications of their possible biological activity and utility.
复制标题
H2S的氧化还原化学和化学生物学,水生硫化物和衍生物种:它们可能的生物活性和实用性的影响。
DOI:
10.1016/j.freeradbiomed.2014.09.007
复制
发表时间:
2014-12
影响因子:
7.4
通讯作者:
Fukuto, Jon M.
中科院分区:
文献类型:
--
作者:
Ono, Katsuhiko;Akaike, Takaaki;Sawa, Tomohiro;Kumagai, Yoshito;Wink, David A.;Tantillo, Dean J.;Hobbs, Adrian J.;Nagy, Peter;Xian, Ming;Lin, Joseph;Fukuto, Jon M.
Hydrogen sulfide (H2S) is an endogenously generated and putative signaling/effector molecule. In spite of its numerous reported functions, the chemistry by which it elicits its functions is not understood. Moreover, recent studies allude to the existence of other sulfur species besides H2S that may play critical physiological roles. Herein, the basic chemical biology of H2S as well as other related or derived species is discussed and reviewed. A particular focus of this review are the per- and poly-sulfides which are likely in equilibrium with free H2S and which may be important biological effectors themselves.
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