Redox chemistry and chemical biology of H2S, hydropersulfides, and derived species: implications of their possible biological activity and utility.

Redox chemistry and chemical biology of H2S, hydropersulfides, and derived species: implications of their possible biological activity and utility.
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H2S的氧化还原化学和化学生物学,水生硫化物和衍生物种:它们可能的生物活性和实用性的影响。

DOI:
10.1016/j.freeradbiomed.2014.09.007
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发表时间:
2014-12
影响因子:
7.4
通讯作者:
Fukuto, Jon M.
Fukuto, Jon M.
中科院分区:
医学1区
文献类型:
--
作者:
Ono, Katsuhiko;Akaike, Takaaki;Sawa, Tomohiro;Kumagai, Yoshito;Wink, David A.;Tantillo, Dean J.;Hobbs, Adrian J.;Nagy, Peter;Xian, Ming;Lin, Joseph;Fukuto, Jon M.

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硫化氢(H_2S)是一种内源性的信号/效应分子。尽管它有许多已报道的功能,但它引发其功能的化学机制尚不清楚。此外,最近的研究暗示,除了H_2S之外,还存在其他可能起关键生理作用的硫物种。本文对硫化氢以及其他相关或衍生物种的基本化学生物学进行了讨论和综述。这篇综述的一个特别的焦点是全硫化物和多硫化物,它们可能与游离的H_2S处于平衡状态,并且可能是重要的生物效应本身。
Hydrogen sulfide (H2S) is an endogenously generated and putative signaling/effector molecule. In spite of its numerous reported functions, the chemistry by which it elicits its functions is not understood. Moreover, recent studies allude to the existence of other sulfur species besides H2S that may play critical physiological roles. Herein, the basic chemical biology of H2S as well as other related or derived species is discussed and reviewed. A particular focus of this review are the per- and poly-sulfides which are likely in equilibrium with free H2S and which may be important biological effectors themselves.
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