Minke whale genome and aquatic adaptation in cetaceans.
Minke whale genome and aquatic adaptation in cetaceans.
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DOI：
10.1038/ng.2835
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发表时间：
2014-01
期刊：
影响因子：
30.8
通讯作者：
Lee JH
中科院分区：
文献类型：
--
作者：
Yim HS;Cho YS;Guang X;Kang SG;Jeong JY;Cha SS;Oh HM;Lee JH;Yang EC;Kwon KK;Kim YJ;Kim TW;Kim W;Jeon JH;Kim SJ;Choi DH;Jho S;Kim HM;Ko J;Kim H;Shin YA;Jung HJ;Zheng Y;Wang Z;Chen Y;Chen M;Jiang A;Li E;Zhang S;Hou H;Kim TH;Yu L;Liu S;Ahn K;Cooper J;Park SG;Hong CP;Jin W;Kim HS;Park C;Lee K;Chun S;Morin PA;O'Brien SJ;Lee H;Kimura J;Moon DY;Manica A;Edwards J;Kim BC;Kim S;Wang J;Bhak J;Lee HS;Lee JH
鲸鱼从陆地生物到水生生物的转变是一个重大的进化事件。在这里，我们报告了小须鲸基因组的全基因组测序和重新组装，以及三只小须鲸、一头长须鲸、一只宽吻海豚和一只无鳍鼠海豚的全基因组序列。我们的比较基因组分析发现，与应激反应蛋白和无氧代谢相关的基因家族在鲸鱼谱系中有所扩展，而与体毛和感觉受体相关的基因家族则有所收缩。我们的分析还发现了鲸鱼特有的基因突变，这些基因编码抗氧化剂和控制血压和盐浓度的酶。总体而言，鲸鱼基因组序列显示出与水生环境中生命所需的生理和形态变化相关的独特特征，其特征是抵抗由缺氧、活性氧增加和高盐水平引起的生理压力。
The shift from terrestrial to aquatic life by whales was a substantial evolutionary event. Here we report the whole-genome sequencing and de novo assembly of the minke whale genome, as well as the whole-genome sequences of three minke whales, a fin whale, a bottlenose dolphin and a finless porpoise. Our comparative genomic analysis identified an expansion in the whale lineage of gene families associated with stress-responsive proteins and anaerobic metabolism, whereas gene families related to body hair and sensory receptors were contracted. Our analysis also identified whale-specific mutations in genes encoding antioxidants and enzymes controlling blood pressure and salt concentration. Overall the whale-genome sequences exhibited distinct features that are associated with the physiological and morphological changes needed for life in an aquatic environment, marked by resistance to physiological stresses caused by a lack of oxygen, increased amounts of reactive oxygen species and high salt levels.
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影响因子：
3.3
作者：
Hahn, Matthew W.;Demuth, Jeffery P.;Han, Sang-Gook
通讯作者：
Han, Sang-Gook
影响因子：
14.9
作者：
Bairoch, A;Apweiler, R
通讯作者：
Apweiler, R
影响因子：
14.9
作者：
Bru C;Courcelle E;Carrère S;Beausse Y;Dalmar S;Kahn D
通讯作者：
Kahn D
影响因子：
14.9
作者：
Chenna, R;Sugawara, H;Thompson, JD
通讯作者：
Thompson, JD
影响因子：
14.9
作者：
UniProt Consortium
通讯作者：
UniProt Consortium