The role of the systemic inflammatory response in predicting outcomes in patients with operable cancer: Systematic review and meta-analysis.
The role of the systemic inflammatory response in predicting outcomes in patients with operable cancer: Systematic review and meta-analysis.
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DOI：
10.1038/s41598-017-16955-5
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发表时间：
2017-12-01
影响因子：
4.6
通讯作者：
McMillan DC
中科院分区：
文献类型：
--
作者：
Dolan RD;Lim J;McSorley ST;Horgan PG;McMillan DC
癌症仍然是全球死亡的主要原因，全身炎症反应（SIR）升高与可手术癌症患者的生存率降低相关。这篇综述的目的是研究证据的作用，全身炎症为基础的预后评分与可手术的癌症患者。截至2016年底，在MEDLINE、EMBASE和CDSR数据库中使用针对人体研究的英语医学主题词进行了广泛的文献综述。SIR在肿瘤类型和地理位置之间具有独立的预后价值。特别是中性粒细胞淋巴细胞比率（NLR）（n = 158）、血小板淋巴细胞比率（PLR）（n = 68）、淋巴细胞单核细胞比率（LMR）（n = 21）和格拉斯哥预后评分/改良格拉斯哥预后评分（GPS/mGPS）（n = 60）得到一致验证。在荟萃分析中，NLR升高与总生存期（OS）（p < 0.00001）/癌症特异性生存期（CSS）（p <0.00001）、LMR升高与OS（p <0.00001）/CSS（p < 0.00001）和PLR升高与OS（p < 0.00001）/CSS（p = 0.005）之间存在显著相关性。GPS/mGPS升高与OS（p < 0.00001）/CSS（p <0.00001）之间也存在显著相关性。这些结果巩固了NLR、PLR、LMR和GPS/mGPS在可切除癌症患者中的预后价值。对于NLR/GPS/mGPS尤其如此，其应构成常规术前和术后检查的一部分。
Cancer remains a leading causes of death worldwide and an elevated systemic inflammatory response (SIR) is associated with reduced survival in patients with operable cancer. This review aims to examine the evidence for the role of systemic inflammation based prognostic scores in patients with operable cancers. A wide-ranging literature review using targeted medical subject headings for human studies in English was carried out in the MEDLINE, EMBASE, and CDSR databases until the end of 2016. The SIR has independent prognostic value, across tumour types and geographical locations. In particular neutrophil lymphocyte ratio (NLR) (n = 158), platelet lymphocyte ratio (PLR) (n = 68), lymphocyte monocyte ratio (LMR) (n = 21) and Glasgow Prognostic Score/ modified Glasgow Prognostic Score (GPS/mGPS) (n = 60) were consistently validated. On meta-analysis there was a significant relationship between elevated NLR and overall survival (OS) (p < 0.00001)/ cancer specific survival (CSS) (p < 0.00001), between elevated LMR and OS (p < 0.00001)/CSS (p < 0.00001), and elevated PLR and OS (p < 0.00001)/CSS (p = 0.005). There was also a significant relationship between elevated GPS/mGPS and OS (p < 0.00001)/CSS (p < 0.00001). These results consolidate the prognostic value of the NLR, PLR, LMR and GPS/mGPS in patients with resectable cancers. This is particularly true for the NLR/GPS/mGPS which should form part of the routine preoperative and postoperative workup.
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影响因子：
8.8
作者：
Chen, Z-Y;Raghav, K.;Lieu, C. H.;Jiang, Z-Q;Eng, C.;Vauthey, J-N;Chang, G. J.;Qiao, W.;Morris, J.;Hong, D.;Hoff, P.;Tran, H.;Menter, D. G.;Heymach, J.;Overman, M.;Kopetz, S.
通讯作者：
Kopetz, S.
影响因子：
2.5
作者：
Bagante F;Tran TB;Postlewait LM;Maithel SK;Wang TS;Evans DB;Hatzaras I;Shenoy R;Phay JE;Keplinger K;Fields RC;Jin LX;Weber SM;Salem A;Sicklick JK;Gad S;Yopp AC;Mansour JC;Duh QY;Seiser N;Solorzano CC;Kiernan CM;Votanopoulos KI;Levine EA;Poultsides GA;Pawlik TM
通讯作者：
Pawlik TM
影响因子：
8.8
作者：
Bhindi B;Hermanns T;Wei Y;Yu J;Richard PO;Wettstein MS;Templeton A;Li K;Sridhar SS;Jewett MA;Fleshner NE;Zlotta AR;Kulkarni GS
通讯作者：
Kulkarni GS
影响因子：
3.4
作者：
Bain, BJ
通讯作者：
Bain, BJ
术前中性粒细胞与淋巴细胞比率升高预示接受肝切除术的肝内胆管癌患者预后不良。
影响因子：
--
作者：
Chen, Qing;Yang, Liu-Xiao;Dai, Zhi
通讯作者：
Dai, Zhi